Bioinformatic Methods I

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Bioinformatic Methods I

University of Toronto

Large-scale biology projects such as the sequencing of the human genome and gene expression surveys using RNA-seq, microarrays and other technologies have created a wealth of data for biologists. However, the challenge facing scientists is analyzing and even accessing these data to extract useful information pertaining to the system being studied. This course focuses on employing existing bioinformatic resources – mainly web-based programs and databases – to access the wealth of data to answer questions relevant to the average biologist, and is highly hands-on. Topics covered include multiple sequence alignments, phylogenetics, gene expression data analysis, and protein interaction networks, in two separate parts. The first part, Bioinformatic Methods I (this one), deals with databases, Blast, multiple sequence alignments, phylogenetics, selection analysis and metagenomics. This, the second part, Bioinformatic Methods II, covers motif searching, protein-protein interactions, structural bioinformatics, gene expression data analysis, and cis-element predictions. This pair of courses is useful to any student considering graduate school in the biological sciences, as well as students considering molecular medicine. Both provide an overview of the many different bioinformatic tools that are out there. These courses are based on one taught at the University of Toronto to upper-level undergraduates who have some understanding of basic molecular biology. If you're not familiar with this, something like https://learn.saylor.org/course/bio101 might be helpful. No programming is required for this course....

Только онлайн-курсы

Начните сейчас и учитесь по собственному графику.

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Предполагаемая нагрузка: 12-18 hours videos and labs

Прибл. 12 ч. на завершение

English

Субтитры: English

Приобретаемые навыки

Genetic AnalysisBioinformatics AnalysisEvolutionComparative Genomics

Только онлайн-курсы

Начните сейчас и учитесь по собственному графику.

Гибкие сроки

Назначьте сроки сдачи в соответствии со своим графиком.

Предполагаемая нагрузка: 12-18 hours videos and labs

Прибл. 12 ч. на завершение

English

Субтитры: English

Программа курса: что вы изучите

1

Раздел

3 ч. на завершение

NCBI/Blast I

In this module we'll be exploring the amazing resources available at NCBI, the National Centre for Biotechnology Information, run by the National Library of Medicine in the USA. We'll also be doing a Blast search to find similar sequences in the enormous NR sequence database. We can use similar sequences to infer homology, which is the primary predictor of gene or protein function. ...

4 видео (всего 52 мин.), 4 материалов для самостоятельного изучения, 1 тест

4 видео

Introduction1мин

Lecture25мин

Lab Discussion24мин

Summaryмин

4 материала для самостоятельного изучения

Acknowledgements10мин

Course Logistics10мин

Lecture Materials10мин

Lab 1 -- Exploring NCBI30мин

1 практическое упражнение

Lab 1 Quiz6мин

2

Раздел

3 ч. на завершение

Blast II/Comparative Genomics

In this module we'll continue exploring the incredible resources available at NCBI, the National Centre for Biotechnology Information. We will be performing several different kinds of Blast searches: BlastP, PSI-Blast, and Translated Blast. We can use similar sequences identified by such methods to infer homology, which is the primary predictor of gene or protein function. We'll also be comparing parts of the genomes of a couple of different species, to see how similar they are....

4 видео (всего 58 мин.), 2 материалов для самостоятельного изучения, 1 тест

4 видео

Introduction2мин

Lecture32мин

Lab Discussion23мин

Summaryмин

2 материала для самостоятельного изучения

Lecture Materials10мин

Lab 2 -- Advanced Blast and Comparative Genomics30мин

1 практическое упражнение

Lab 2 Quiz6мин

3

Раздел

2 ч. на завершение

Multiple Sequence Alignments

In this module we'll be doing multiple sequence alignments with Clustal (as implemented in MEGA), DiAlign, and MAFFT. Multiple sequences alignments can tell you where in a sequence the conserved and variable regions are, which is important for understanding the biology of the sequences under investigation. It also has practical applications, such as being able to design PCR primers that will amplify sequences from a number of different species, for example....

4 видео (всего 42 мин.), 2 материалов для самостоятельного изучения, 1 тест

4 видео

Introduction1мин

Lecture23мин

Lab Discussion16мин

Summaryмин

2 материала для самостоятельного изучения

Lecture Materials10мин

Lab 3 -- Multiple Sequence Alignment30мин

1 практическое упражнение

Lab 3 Quiz6мин

4

Раздел

10 минуты на завершение

Review: NCBI/Blast I, Blast II/Comparative Genetics, and Multiple Sequence Alignments

...

1 тест

1 практическое упражнение

Quiz: Modules 1-310мин

Преподаватель

Nicholas James Provart

Professor

Cell & Systems Biology

О University of Toronto

Established in 1827, the University of Toronto has one of the strongest research and teaching faculties in North America, presenting top students at all levels with an intellectual environment unmatched in depth and breadth on any other Canadian campus. ...

Часто задаваемые вопросы

When will I have access to the lectures and assignments?
Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.
What will I get if I purchase the Certificate?
When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.
What is the refund policy?
Is financial aid available?

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Bioinformatic Methods I