Об этом курсе: Imagine if there were an organ in your body that weighed as much as your brain, that affected your health, your weight, and even your behavior. Wouldn’t you want to know more about it? There is such an organ — the collection of microbes in and on your body, your human microbiome.
Автор: Колорадский университет в Боулдере, Система университетов штата Колорадо, Калифорнийский университет в Сан-Диего
Преподаватели: Rob Knight, Professor
Pediatrics and Computer Science & Engineering. Director, Center for Microbiome Innovation, University of California, San Diego
Преподаватели: Dr. Jessica L. Metcalf, Senior Research Associate
BioFrontiers Institute
Преподаватели: Dr. Katherine R. Amato, Postdoctoral Research Associate
Department of Anthropology, BioFrontiers Institute
| Язык | English, Субтитры: Catalan |
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Программа курса
НЕДЕЛЯ 1
Introduction to Microbes and the Human Microbiome
Welcome Citizen Scientists! We're very pleased to have you join us on an exploration of the human microbiome. This is a fascinating area of study, and we hope you will find this six-module course worthwhile. Each module's content will be presented in similar fashion; our team will introduce topics by way of pre-recorded video lectures interspersed with guest interviews by subject matter experts. Module 1 will provide a broad overview about microbes and their diversity on earth and in the human body.
10 видео, 3 материалов для самостоятельного изучения
- Видео: Introduction
- Reading: About This Course
- Видео: Welcome to the Course
- Видео: What are Microbes?
- Видео: Interview: Jack Gilbert
- Видео: Interview: Valerie McKenzie
- Видео: The Human Microbiome
- Видео: Where Do You Get Your Microbes?
- Видео: Web interview: Maria Gloria Dominguez-Bello
- Видео: Web interview: Elizabeth Costello
- Видео: Rob's Module 1 wrap-up
- Reading: Assignments
- Reading: Part 1: You and Your Gut
Оцениваемый: Introduction to Microbes and the Human Microbiome
Оцениваемый: Personal Microbiome Project Part I: Brainstorming
НЕДЕЛЯ 2
Studying the Microbiome
In this module, we will dive into the fundamentals of how we study the human microbiome. We highlight recent advances in microbiome research methods and take you on a tour of the Knight lab. Please keep in mind, that Modules 2 and 3 are meant to provide a glimpse into our world of data generation and analysis. Modules 4, 5, and 6 will be less technical and provide a broad overview of fascinating research on the human microbiome. Stick with us!
9 видео, 2 материалов для самостоятельного изучения
- Видео: How we study the microbiome: Introduction
- Видео: The history of studying microbes with Norm Pace
- Видео: Basics of high-throughput DNA sequencing
- Видео: Demo: Tour of the Knight Lab
- Видео: 'Omics' and other useful technologies
- Видео: Interview: Luke Thompson
- Видео: Web interview: Janet Jansson
- Видео: Web interview: Pieter Dorrestein
- Видео: Rob's Module 2 wrap-up
- Reading: Assignments
- Reading: Part 1: You and Your Gut (continued)
Оцениваемый: Studying the Microbiome
НЕДЕЛЯ 3
Making Sense Out of Microbial Data
This module highlights the basics of generating and analyzing microbiome data. We will also discuss how computational scientists are revolutionizing the development of tools for analyzing large, complex biological data sets and show you some of the cool ways that we visualize data! This module will help you understand data plots in later modules, but do not get discouraged if the material here is too technical, a full understanding is not required to complete the course!
7 видео, 2 материалов для самостоятельного изучения
- Видео: How do we identify a microbe?
- Видео: Web interview: Philip Hugenholtz
- Видео: Basics of alpha-diversity with fuzzy microbe demo
- Видео: Beta-diversity, and visualizing differences
- Видео: Demo: EMPeror, a QIIME visualization tool
- Видео: Web interview: Gregory Caporaso
- Видео: Rob's Week 3 wrap-up
- Reading: Assignments
- Reading: Part 1: You and Your Gut (continued)
Оцениваемый: Making Sense Out of Microbial Data
НЕДЕЛЯ 4
The Human Gut Microbiome and Your Health
Now that we've given you some background about the methods we use to analyze microbial data, it's time for us to talk more about recent discoveries in microbiome research. This module will focus on the main factors impacting the gut microbiota as well as the influence of the gut microbiota on nutrition and gut health. This is the fun part, so get excited!
8 видео, 1 материал для самостоятельного изучения
- Видео: Impact of diet and age on the gut microbiota
- Видео: Obesity and the gut microbiota
- Видео: Human microbiome and gut disease
- Видео: Interview: On location in Tanzania with Martin Blaser
- Видео: Interview: On location in Tanzania with Jeff Leach
- Видео: Interview: On location in Tanzania with Maria Gloria Dominguez-Bello
- Видео: Manipulating the microbiome through fecal transplants
- Видео: Rob's Module 4 wrap-up
- Reading: Assignments
Оцениваемый: The Human Gut Microbiome and Your Health
Оцениваемый: Personal Microbiome Project Part I: Reflection Questions
НЕДЕЛЯ 5
Gut Microbe-Host Interactions: Beyond Nutrition
You're more than halfway through the course! We hope you've been learning lots of new, exciting things about the human gut microbiota! In this module, we'll shift the focus from nutrition and gut health to the rest of your body. How do your gut microbes and your immune system interact? What about your nervous system? Does the gut microbiota play a role in allergies and stress?
11 видео, 1 материал для самостоятельного изучения
- Видео: Gut microbiota interactions with the immune system
- Видео: Gut microbiota, autoimmune diseases, and allergies
- Видео: Web interview: Sarkis Mazmanian
- Видео: Interview: Cathy Lozupone
- Видео: The gut-brain axis
- Видео: Post-mortem human microbiome
- Видео: Zech on machine learning
- Видео: Web interview: Sibyl Bucheli
- Видео: Web interview: David Carter
- Видео: Web interview: Charlotte Carter
- Видео: Rob's Module 5 wrap-up
- Reading: Assignments
Оцениваемый: Gut Microbe-Host Interactions: Beyond Nutrition
НЕДЕЛЯ 6
What's in the American Gut
We will wrap up the course in this module by discussing what's in the American Gut. Rob will walk us through results from the American Gut Project and compare results from Jeff Leach and Michael Pollan. We will also hear from Michael Pollan on the importance of microbiome research and how it has changed the way he thinks about his health and what he eats.
8 видео, 4 материалов для самостоятельного изучения
- Видео: The American Gut Project and crowd-funding
- Видео: Interview: Tom Cech
- Видео: Collecting samples
- Видео: Interview: Daniel McDonald
- Видео: Michael Pollan vs. Jeff Leach: American Gut results explained
- Видео: Web interview: Michael Pollan
- Видео: Comparing the American Gut to other populations
- Видео: Rob's Module 6 wrap-up and thank you's
- Reading: Assignments
- Reading: Closing Remarks
- Reading: Acknowledgements
- Reading: Post-Course Survey
Оцениваемый: What's in the American Gut
Оцениваемый: Personal Microbiome Project Part II
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Авторы
Колорадский университет в Боулдере
CU-Boulder is a dynamic community of scholars and learners on one of the most spectacular college campuses in the country. As one of 34 U.S. public institutions in the prestigious Association of American Universities (AAU), we have a proud tradition of academic excellence, with five Nobel laureates and more than 50 members of prestigious academic academies.
Система университетов штата Колорадо
The University of Colorado is a recognized leader in higher education on the national and global stage. We collaborate to meet the diverse needs of our students and communities. We promote innovation, encourage discovery and support the extension of knowledge in ways unique to the state of Colorado and beyond.
Калифорнийский университет в Сан-Диего
UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 10 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom—life is their laboratory.
Рейтинги и отзывы
Wonderful course, lots of amazing information and I appreciate learning about this topic as I would like to apply some of the concepts to better my family's health. Highly recommend it!
Fantastic foundational course in the gut microbiome. I was impressed by the section on genetic sequencing and learned a lot. I would love a follow-on course in this subject to learn more about specific gut bacteria and impact on human health. For anyone interested in getting a solid base in gut biome science, I would start with this course.
Great class, get ready to learn. Lots of reading assignments, which I really liked. Very current research that they are presenting to you here and the researchers that you'll hear from in this are absolutely world class.
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Very good, with a lot of resources to thing about our own health and body