Medical Neuroscience
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Medical Neuroscience
Duke University
Об этом курсе
4.9
1,021 ratings
Medical Neuroscience explores the functional organization and neurophysiology of the human central nervous system, while providing a neurobiological framework for understanding human behavior. In this course, you will discover the organization of the neural systems in the brain and spinal cord that mediate sensation, motivate bodily action, and integrate sensorimotor signals with memory, emotion and related faculties of cognition. The overall goal of this course is to provide the foundation for understanding the impairments of sensation, action and cognition that accompany injury, disease or dysfunction in the central nervous system. The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system.
This online course is designed to include all of the core concepts in neurophysiology and clinical neuroanatomy that would be presented in most first-year neuroscience courses in schools of medicine. However, there are some topics (e.g., biological psychiatry) and several learning experiences (e.g., hands-on brain dissection) that we provide in the corresponding course offered in the Duke University School of Medicine on campus that we are not attempting to reproduce in Medical Neuroscience online. Nevertheless, our aim is to faithfully present in scope and rigor a medical school caliber course experience.
This course comprises six units of content organized into 12 weeks, with an additional week for a comprehensive final exam:
- Unit 1 Neuroanatomy (weeks 1-2). This unit covers the surface anatomy of the human brain, its internal structure, and the overall organization of sensory and motor systems in the brainstem and spinal cord.
- Unit 2 Neural signaling (weeks 3-4). This unit addresses the fundamental mechanisms of neuronal excitability, signal generation and propagation, synaptic transmission, post synaptic mechanisms of signal integration, and neural plasticity.
- Unit 3 Sensory systems (weeks 5-7). Here, you will learn the overall organization and function of the sensory systems that contribute to our sense of self relative to the world around us: somatic sensory systems, proprioception, vision, audition, and balance senses.
- Unit 4 Motor systems (weeks 8-9). In this unit, we will examine the organization and function of the brain and spinal mechanisms that govern bodily movement.
- Unit 5 Brain Development (week 10). Next, we turn our attention to the neurobiological mechanisms for building the nervous system in embryonic development and in early postnatal life; we will also consider how the brain changes across the lifespan.
- Unit 6 Cognition (weeks 11-12). The course concludes with a survey of the association systems of the cerebral hemispheres, with an emphasis on cortical networks that integrate perception, memory and emotion in organizing behavior and planning for the future; we will also consider brain systems for maintaining homeostasis and regulating brain state.
Приобретаемые навыки
BrainNeurological DisordersNeurobiologyNeurology
Программа курса: что вы изучите
1
Раздел
Getting Started in Medical Neuroscience
<p>Let's get started in Medical Neuroscience! Each module in Medical Neuroscience will begin with a brief description like this that provides you with an overview of the module. In this first module, you will get to know something about Prof. White and his career in neuroscience; you will understand the scope of Medical Neuroscience, its learning resources, your responsibilities for maximizing your benefit in this course, and you will learn Prof. White's tips on how best to study and learn.</p><p> At the end of this module, please take the ungraded preliminary quiz, "Are you ready for Medical Neuroscience", to self-assess your background knowledge. Your score on this quiz will not count toward your overall score in this course. However, you should be able to pass this quiz (score 70% or better) if you are ready for the academic challenge of this course. Students who are likely to achieve their goals in Medical Neuroscience should be able to successfully answer nearly all of the quiz questions on their first attempt and feel comfortable with assessment questions at this level of knowledge.</p>
5 видео (всего 75 мин.), 2 материалов для самостоятельного изучения, 1 тест
5 видео
The Scope of Medical Neuroscience11мин
Learning resources for Medical Neuroscience32мин
Your Part!13мин
"Neur-run" with Professor White3мин
2 материала для самостоятельного изучения
Learning Objectives10мин
Your Mentor Team10мин
1 практическое упражнение
Preliminary Quiz: Are you ready for Medical Neuroscience?22мин
Neuroanatomy: Introducing the Human Brain
Your introduction to Medical Neuroscience continues as you experience in this module a brief introduction to the human brain, its component cells, and some basic anatomical conventions for finding your way around the human central nervous system.
4 видео (всего 79 мин.), 1 материал для самостоятельного изучения, 1 тест
4 видео
Functional Microanatomy of Neurons31мин
Non-Neural Cells of the CNS20мин
Basic Orientation in the Human CNS7мин
1 материал для самостоятельного изучения
Introduction, Learning Objectives and Recommended Reading10мин
1 практическое упражнение
Cells of the CNS and Basic Orientation18мин
2
Раздел
Neuroanatomy: Surface Anatomy of the Human CNS
We now begin in earnest our lessons on neuroanatomy with the surface of the human brain, including a brief run through the cranial nerves and the blood supply to the CNS. In this module, you will learn the basic subdivisions of the vertebrate nervous system; however, your focus should be on the cerebral cortex. Along the way, you will be challenged to "build a digital brain" that should help you generate and improve your mental “model” of the cerebral hemispheres of the human brain. Another great way to refine your mental model is through sketching and crafting, so please do the learning objectives that are designed to help you make visible (and tangible) your understanding of the cerebral hemispheres.
12 видео (всего 129 мин.), 2 материалов для самостоятельного изучения, 2 тестов
12 видео
Medial Surface of the Brain5мин
Finding the Central Sulcus6мин
Ventral Surface of the Brain8мин
Building a Digital Brain (Fingers to Gyri)11мин
Surface Anatomy of the Brainstem4мин
Blood Supply to the Brain15мин
Overview of the Cranial Nerves19мин
Overview of the Spinal Nerves8мин
Localizing the Cranial Nerves13мин
Cranial Nerve Function, part 116мин
Cranial Nerve Function, part 211мин
2 материала для самостоятельного изучения
Learning Objectives / Recommended Readings10мин
Learning Objectives / Recommended Readings10мин
2 практического упражнения
Cerebral Cortex, Brainstem, and Blood Supply24мин
Cranial and Spinal Nerves16мин
Neuroanatomy: Internal Anatomy of the Human CNS
12 видео (всего 160 мин.), 2 материалов для самостоятельного изучения, 2 тестов
12 видео
Cranial Nerve Nuclei, part 112мин
Cranial Nerve Nuclei, part 219мин
Cranial Nerve Nuclei, part 317мин
Cranial Nerve Nuclei, part 417мин
Internal Anatomy of the Spinal Cord - Gray and White Matter11мин
Internal Anatomy of the Spinal Cord -Longitudinal Organization11мин
Internal Anatomy of the Spinal Cord In Cross Sections6мин
Ventricles8мин
Overview of the Internal Capsule and Deep Gray Matter8мин
Localizing the Internal Capsule and Deep Gray Matter In Brain Slabs9мин
Localizing the Internal Capsule and Deep Gray Matter In Sylvius Atlases12мин
2 материала для самостоятельного изучения
Learning Objectives / Recommended Readings10мин
Learning Objectives / Recommended Readings10мин
2 практического упражнения
Brainstem and Spinal Cord22мин
Forebrain26мин
3
Раздел
Neural Signaling: Electrical Excitability and Signal Propagation
We now turn our attention from the tangible (human neuroanatomy) to the physiological as we explore the means by which neurons generate, propagate and communicate electrical signals. After exploring those structures in the human brain that are visible to the unaided eye, we must now sharpen our focus and zoom-in, as it were, to the unitary level of organization and function in the central nervous system: to the level of individual neurons and their component parts that are crucial for neural signaling.
9 видео (всего 142 мин.), 1 материал для самостоятельного изучения, 1 тест
9 видео
Ionic Basis of the Resting Membrane Potential, part 114мин
Ionic Basis of the Resting Membrane Potential, part 215мин
Ionic Basis of the Action Potential, part 118мин
Ionic Basis of the Action Potential, part 212мин
Ionic Basis of the Action Potential, part 315мин
Molecular Mechanisms of Action Potential Generation, part 120мин
Molecular Mechanisms of Action Potential Generation, part 29мин
Propagation of Action Potentials20мин
1 материал для самостоятельного изучения
Learning Objectives / Recommended Readings10мин
1 практическое упражнение
Generating and Propagating Electrical Signals20мин
4
Раздел
Neural Signaling: Synaptic Transmission and Synaptic Plasticity
Let’s continue our studies of neural signaling by learning about what happens at synaptic junctions, where the terminal ending of one neuron meets a complementary process of another excitable cell.
13 видео (всего 226 мин.), 2 материалов для самостоятельного изучения, 2 тестов
13 видео
Synaptic Transmission, part 215мин
Neurotransmitters, part 115мин
Neurotransmitters, part 222мин
Ionotropic Neurotransmitters Receptors, part 117мин
Ionotropic Neurotransmitters Receptors, part 211мин
Metabotropic Neurotransmitters Receptors and Postsynaptic Mechanisms11мин
Synaptic Integration25мин
Long-Term Potentiation and Depression, part 122мин
Long-Term Potentiation and Depression, part 217мин
Long-Term Potentiation and Depression, part 314мин
Spike-Timing Dependent synaptic Plasticity19мин
Hebb's Postulate11мин
2 материала для самостоятельного изучения
Learning Objectives / Recommended Readings10мин
Learning Objectives / Recommended Readings10мин
2 практического упражнения
Synaptic Transmission24мин
Synaptic Plasticity18мин
4.9
56%
83%
Лучшие рецензии
автор: KR•Dec 22nd 2016
I have not really taken any Neuroscience courses and I have to say this was very challenging with my already full-time load at school but I did it! Yay! I love Dr. White he is an awesome professor!
автор: RR•Nov 25th 2016
While I greatly respect Dr. White's obvious immense knowledge of the neural anatomy, I feel taking this course did very little beyond showing me that perhaps medicine and anatomy wasn't for me.
Преподаватель
Leonard E. White, Ph.D.
Associate ProfessorDepartment of Neurology, Department of Neurobiology, Duke University School of Medicine; Department of Psychology & Neuroscience, Trinity College of Arts & Sciences; Director of Education, Duke Institute for Brain Sciences; Duke University
О Duke University
Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world.
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