Об этом курсе
4.8
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94 reviews
While the human genome sequence has transformed our understanding of human biology, it isn’t just the sequence of your DNA that matters, but also how you use it! How are some genes activated and others are silenced? How is this controlled? The answer is epigenetics. Epigenetics has been a hot topic for research over the past decade as it has become clear that aberrant epigenetic control contributes to disease (particularly to cancer). Epigenetic alterations are heritable through cell division, and in some instances are able to behave similarly to mutations in terms of their stability. Importantly, unlike genetic mutations, epigenetic modifications are reversible and therefore have the potential to be manipulated therapeutically. It has also become clear in recent years that epigenetic modifications are sensitive to the environment (for example diet), which has sparked a large amount of public debate and research. This course will give an introduction to the fundamentals of epigenetic control. We will examine epigenetic phenomena that are manifestations of epigenetic control in several organisms, with a focus on mammals. We will examine the interplay between epigenetic control and the environment and finally the role of aberrant epigenetic control in disease. All necessary information will be covered in the lectures, and recommended and required readings will be provided. There are no additional required texts for this course. For those interested, additional information can be obtained in the following textbook. Epigenetics. Allis, Jenuwein, Reinberg and Caparros. Cold Spring Harbour Laboratory Press. ISBN-13: 978-0879697242 | Edition: 1...
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Предполагаемая нагрузка: 7 weeks of study, 6-8 hours/week

Прибл. 29 ч. на завершение
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Субтитры: English

Приобретаемые навыки

CancerMolecular BiologyCancer EpigeneticsDna Methylation
Globe

Только онлайн-курсы

Начните сейчас и учитесь по собственному графику.
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Гибкие сроки

Назначьте сроки сдачи в соответствии со своим графиком.
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Предполагаемая нагрузка: 7 weeks of study, 6-8 hours/week

Прибл. 29 ч. на завершение
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English

Субтитры: English

Программа курса: что вы изучите

1

Раздел
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2 ч. на завершение

Week 1 - Introduction to Epigenetic Control

An introduction to and definition of epigenetic control of gene expression, and its importance in normal development. We will learn what chromatin is, and how its composition and packaging can alter gene expression. We’ll also discuss the best-characterised epigenetic modification, DNA methylation, and how it is not only implicated in regulating gene expression, but also in maintaining genome stability. ...
Reading
7 видео (всего 65 мин.), 5 материалов для самостоятельного изучения, 1 тест
Video7 видео
1.1 Introduction to the concepts of epigenetic control10мин
1.2 Mitotic heritability of epigenetic marks10мин
1.3 Chromatin and the nucleosome6мин
1.4 Chromatin compaction - heterochromatin versus euchromatin9мин
1.5 DNA methylation at CpG islands11мин
1.6 DNA methylation at intergenic regions and repetitive elements15мин
Reading5 материала для самостоятельного изучения
Course syllabus10мин
Teaching team10мин
Start of course survey10мин
Assessment and grading policy10мин
Week 1 and 2 resources10мин
Quiz1 практическое упражнение
Week 1 quiz - contributes 8% towards your final grade20мин

2

Раздел
Clock
2 ч. на завершение

Week 2 - Epigenetic Modifications and Organisation of the Nucleus

We’ll discuss the molecular mechanisms for regulating gene expression in some detail, from how the DNA is packaged at a local level, right up to how the chromatin is positioned within the nucleus. We’ll learn about the chromatin modifications implicated in gene silencing and activation, the role of non-coding RNA, and higher order chromatin structures. This week will provide you with a good understanding of the basic mechanisms that will help you understand the processes we discuss throughout the rest of the course. ...
Reading
9 видео (всего 90 мин.), 1 материал для самостоятельного изучения, 1 тест
Video9 видео
2.2 Histone acetylation and histone methylation12мин
2.3 Chromatin remodelling12мин
2.4 Histone variants8мин
2.5 Noncoding RNAs - microRNAs6мин
2.6 Noncoding RNAs - piRNAs9мин
2.7 Noncoding RNAs - long noncoding RNAs introduction10мин
2.8 Long noncoding RNAs Xist and HOTAIR7мин
2.9 3D organisation of the nucleus and summary of epigenetic marks17мин
Reading1 материал для самостоятельного изучения
Week 1 and 2 resources10мин
Quiz1 практическое упражнение
Week 2 quiz - contributes 8% towards your final grade20мин

3

Раздел
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3 ч. на завершение

Week 3 - Dosage Compensation

X chromosome inactivation is a really well-characterised epigenetic process that is now used as a model system to study epigenetic processes that are relevant more broadly. This is because it uses many epigenetic mechanisms, at many levels, to achieve really stable silencing of a whole chromosome. We’ll learn about this process and how it occurs in a mouse in great detail, which will greatly add to the mechanistic understanding gained in week two. We will then briefly discuss alternate mechanisms for dosage compensation that occur in other organisms. ...
Reading
12 видео (всего 113 мин.), 1 материал для самостоятельного изучения, 1 тест
Video12 видео
3.2 Timing of random and imprinted X chromosome inactivation8мин
3.3 Stages of X inactivation - counting and control of Xist expression13мин
3.4 Control of Xist expression by pluripotency factors6мин
3.5 Stages of X inactivation - choice of which X to inactivate9мин
3.6 Stages of X inactivation - initiation and spreading of silencing11мин
3.7 Stages of X inactivation - establishment of silencing6мин
3.8 Stages of X inactivation - maintenance of silencing e.g. Dnmt18мин
3.9 Stages of X inactivation - maintenance of silencing e.g. Smchd18мин
3.10 X chromosome inactivation summary10мин
3.11 Dosage compensation in flies and worms, compared with mammals8мин
3.12 Lessons from the fly - position effect variegation and screening for epigenetic modifiers10мин
Reading1 материал для самостоятельного изучения
Week 3 resources (including required readings)10мин
Quiz1 практическое упражнение
Week 3 quiz - contributes 12% towards your final grade30мин

4

Раздел
Clock
2 ч. на завершение

Week 4 - Genomic Imprinting and Epigenetic Reprogramming

We’ll learn about the two important periods during development for the erasure and resetting of the epigenome. There are two well-characterised features that are treated differently during epigenetic reprogramming; imprinted genes and repeats. We’ll learn about mechanisms for genomic imprinting, and study three examples in more depth....
Reading
6 видео (всего 68 мин.), 1 материал для самостоятельного изучения, 1 тест
Video6 видео
4.2 Epigenetic reprogramming of imprinted genes and repetitive elements11мин
4.3 Location of imprinted genes in the genome and bisulfite sequencing10мин
4.4 Kcnq1 and H19/Igf2 ICR mechanisms of action and Beckwith Weidemann syndrome17мин
4.5 Snrpn ICR mechanism, Prader Willi and Angelman syndromes13мин
4.6 Summary of epigenetic reprogramming and imprinting6мин
Reading1 материал для самостоятельного изучения
Week 4 resources (including required reading)10мин
Quiz1 практическое упражнение
Week 4 quiz - contributes 12% towards your final grade30мин
4.8
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Лучшие рецензии

автор: DSAug 25th 2018

This is an excellent course that introduces you to fundamental knowledge of several hot topics in the field of epigenetics. Dr. Blewitt herself studies X inactivation, and I learned so much!

автор: BMAug 14th 2017

One of the best organized and implemented courses I have taken so far. For someone who had barely any experience with epigenetics, I feel this gave me a proper introduction to the field.

Преподаватель

Dr. Marnie Blewitt

Head, Molecular Medicine Laboratory
Walter and Eliza Hall Institute of Medical Research

О The University of Melbourne

The University of Melbourne is an internationally recognised research intensive University with a strong tradition of excellence in teaching, research, and community engagement. Established in 1853, it is Australia's second oldest University....

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