Об этом курсе: Not so long ago, it was almost guaranteed that you would die of an infectious disease. In fact, had you been born just 150 years ago, your chances of dying of an infectious disease before you've reached the tender age of 5 would have been extremely high. Since then, science has come a long way in understanding infectious diseases - what they are, how they spread, and how they can be prevented. But diseases like HIV/AIDS, Malaria, Tuberculosis, or the flu are still major killers worldwide, and novel emerging diseases are a constant threat to public health. In addition, the bugs are evolving. Antibiotics, our most potent weapon against bacterial infections, are losing their power because the bacteria are becoming resistant. In this course, we'll explore the major themes of infectious diseases dynamics. After we’ve covered the basics, we'll be looking at the dynamics of the flu, and why we're worried about flu pandemics. We'll be looking at the dynamics of childhood diseases such as measles and whooping cough, which were once considered almost eradicated, but are now making a comeback. We'll explore Malaria, and use it as a case study of the evolution of drug resistance. We'll even be looking at social networks - how diseases can spread from you to your friends to your friends' friends, and so on. And of course we’ll be talking about vaccination too. We’ll also be talking about how mobile phones, social media and crowdsourcing are revolutionizing disease surveillance, giving rise to a new field of digital epidemiology. And yes, we will be talking about Zombies - not human zombies, but zombie ants whose brains are hijacked by an infectious fungus. We're looking forward to having you join us for an exciting course!
Автор: Университет штата Пенсильвания
Преподаватели: Dr. Ottar N. Bjornstad, Professor of Entomology and Biology
Department of Biology
Преподаватели: Dr. Rachel A. Smith, Associate Professor
Department of Communication Arts & Sciences and Human Development & Family Studies
Преподаватели: Dr. Mary L. Poss, Professor of Biology
Department of Biology
Преподаватели: Dr. David P. Hughes, Assistant Professor of Entomology and Biology
Department of Biology
Преподаватели: Dr. Peter Hudson, Willaman Professor of Biology
Department of Biology
Преподаватели: Dr. Matthew Ferrari, Assistant Professor of Biology
Department of Biology
Преподаватели: Dr. Andrew Read, Alumni Professor in the Biological Sciences, and Professor of Entomology
Center for Infectious Disease Dynamics
Преподаватели: Dr. Marcel Salathé, Assistant Professor of Biology
Department of Biology
| Выполнение | 20 hours of videos and quizzes |
| Язык | English |
| Как пройти курс | Чтобы пройти курс, выполните все оцениваемые задания. |
| Оценки пользователей |
Программа курса
НЕДЕЛЯ 1
Course Introduction
Welcome to Epidemics: the Dynamics of Infectious Diseases. This course will teach you about the variety of parasitic organisms that infect humans, animals, and plants, how these parasites spread through populations, and the various methods that we employ to control them.
3 материалов для самостоятельного изучения
- Reading: Course Overview
- Reading: Course Syllabus
- Reading: Glossary of Terms
Pathogens
In the first module, you will learn about the organisms that can infect us and make us sick: pathogens. We will first take a look at the various types of pathogens that exist, and then learn about what it means to be infectious, and what it means to cause disease. After that, we will cover the various methods by which pathogens can transmit from one person to the next, thereby causing an epidemic. You will learn about the most important number in all of epidemiology, R0, and why this number is so important. Finally, we will learn that microorganisms are not always harmful, but can be beneficial to us as well.
7 видео, 1 материал для самостоятельного изучения
- Reading: Module Overview
- Видео: What is an Epidemic?
- Видео: Micro and Macro Parasites
- Видео: Infection and Disease
- Видео: Transmission Types
- Видео: Reproductive Number
- Видео: Epidemic Curve
- Видео: Micro-organisms
Оцениваемый: Summative: Pathogens
НЕДЕЛЯ 2
Hosts
The second module of the course covers host factors that determine the outcome of infection. We will first focus on host immunity and present both the general immune capabilities—the innate immune response—that are encoded in our genes and that provide the initial response to infection and the adaptive immune response, which arises from highly specialized cells that protect against a specific pathogen. You will then learn about the ways that pathogens circumvent these two types of immunity and consider other factors that can contribute to an individual becoming infected or diseased—including genetic factors, other microbes, and how social and emotional factors influence immunity. We will then consider how infection with a microorganism causes disease and how public health officials determine whether a disease outbreak is caused by an infectious organism.
7 видео, 1 материал для самостоятельного изучения
- Reading: Module Overview: Hosts
- Видео: Types of Immunity: Innate Immune System
- Видео: Types of Immunity: Adaptive Immune System
- Видео: Immune Evasion
- Видео: Other Determinants of Susceptibility
- Видео: Social Influences on Immunity
- Видео: Pathogens and Disease
- Видео: Detecting an Infectious Disease Outbreak
Оцениваемый: Summative: Hosts
НЕДЕЛЯ 3
Basics of Ecology
The third module of the course covers ecological factors that influence the dynamic patterns of infectious disease. We will discuss the conditions under which a pathogen can drive its host to extinction. We will look at how the demography of the host may allow the pathogen to persist in some populations but not others. We will talk about how host and pathogen characteristics interact to shape different temporal patterns of disease incidence at the population level and discuss the ecological consequences of infecting more than one host species.
9 видео, 1 материал для самостоятельного изучения
- Reading: Module Overview: Basics of Ecology
- Видео: Pathogens and Host Extinction
- Видео: Force of Infection
- Видео: Cycles
- Видео: Seasonality
- Видео: Flu 1918
- Видео: Host Diversity, Host Range
- Видео: Critical Community Size
- Видео: Pathogen-Microbiome Interactions
- Видео: The 2014 Ebola Outbreak
Оцениваемый: Summative: Basics of Ecology
НЕДЕЛЯ 4
Epidemiology
Where humans live and how they are connected to each other, have strong effects on how infectious diseases can spread. In this module, you will learn about some of the related key concepts of epidemiology. After looking at some fascinating history, we’ll learn about social networks as the ultimate “road map” on which diseases can travel and we’ll talk about how the structure of the network can influence disease dynamics. After that, we’ll cover three topics that all affect infectious disease epidemiology in dramatic ways: human transport systems, population density and so-called superspreaders - individuals who can spread a disease to dozens or even hundreds of other individuals. We’ll close by identifying what information is required for disease surveillance.
8 видео, 1 материал для самостоятельного изучения
- Reading: Module Overview: Epidemiology
- Видео: Roots of Epidemiology
- Видео: Social Networks
- Видео: Structure of Networks
- Видео: Superspreaders
- Видео: Spatial Hetergeneity
- Видео: Movement and Modern Transportation
- Видео: Surveillance and Disclosure
- Видео: Co-Infection Consequences
Оцениваемый: Summative: Epidemiology
НЕДЕЛЯ 5
Vaccination
In module 5 of the course, you will learn about vaccination, one of the most common approaches to the prevention of epidemics. We'll first put vaccination in the context of the many types of public health interventions that that can be used to prevent or treat disease. After that you will learn about the development of the first vaccine, how vaccines work to prevent infection, and the impact that vaccination has had on the prevention of disease worldwide. After that, you will learn about how vaccination can provide protection to everyone, even the unvaccinated, in the population through "herd immunity" and how we can use the structure of social networks within populations to more efficiently achieve this herd protection. Finally we'll learn about how individuals choices about whether or not to get vaccinated can lead to impacts across the whole of the population.
7 видео, 1 материал для самостоятельного изучения
- Reading: Module Overview: Vaccination
- Видео: Introduction to Control
- Видео: Discovery of the First Vaccine
- Видео: Global Impact of Vaccination
- Видео: How Vaccination Works
- Видео: Herd Immunity
- Видео: Social Networks and Targeted Vaccination
- Видео: Vaccination Refusal
Оцениваемый: Summative: Vaccination
НЕДЕЛЯ 6
Control Mechanisms
In module 6 of the course, you will learn about mechanisms involved in controlling epidemics. In these lectures, we will discuss what control mechanisms are trying to do, such as breaking the chain of transmission, and many ways by which animals and humans attempt to achieve control. These means include pharmaceutical and non-pharmaceutical interventions, appearing at individual or population levels. We will describe examples of great successes in eradication, and the reasons why control efforts fail.
10 видео, 1 материал для самостоятельного изучения
- Reading: Module Objectives: Control Mechanisms
- Видео: Eradication and Elimination
- Видео: Social Challenges to Eradication
- Видео: Non-pharmaceutical Interventions: Animals
- Видео: Non-pharmaceutical Interventions: Humans 1
- Видео: Non-pharmaceutical Interventions: Humans 2
- Видео: Behavioral Avoidance
- Видео: Controlling the Vector
- Видео: Consequences of Control
- Видео: Vaccination Ethics
- Видео: New Approaches to an Old Infection
Оцениваемый: Summative: Control Mechanisms
НЕДЕЛЯ 7
Emergence
In module 7 of the course, we’ll look at so-called emerging infectious diseases. These are diseases that are causing new problems. They include infectious agents that are new to humanity, but also infectious agents that were once controlled and are now returning, particularly those that are evolving around formerly very effective public health tools like drugs and vaccines. This means much of the week involves a discussion of evolution. We will look at these emerging diseases and ask, where do they come from and what can be done about them? You will learn about new ideas for managing evolution, and some of the societal challenges involved. We will also look at the related question of how some diseases evolve to be nicer or nastier to their hosts.
7 видео, 1 материал для самостоятельного изучения
- Reading: Module Overview: Emergence
- Видео: Disease Emergence
- Видео: Re-emergence
- Видео: Evolution General
- Видео: Antibiotic and Drug Resistance
- Видео: Management of Resistance
- Видео: Behavioral And Economic Impact
- Видео: Evolution of Virulence
Оцениваемый: Summative: Emergence
НЕДЕЛЯ 8
Global Health
In this final module we explore the global context of epidemics. The world is rapidly changing with the global population increasing and the speed of travel and extent of globalization piling on the pressure of infectious diseases. In this week we set out first to explore a textbook example of disease shaped by the conditions presented by modern living: the disease SARS. We will see how high density living in cities coupled with links to wildlife diseases through markets can create a pandemic. We then explore traditional methods of disease surveillance and then more recent ones afforded to us by the web and networks made possible through google, twitter and other social media. Important to this global view is human behavior, our evolving culture and health. We will also consider emerging disease and the global pattern of diseases across our recent history and how from our earliest beginnings of global travellers we have affected the spread of diseases. Finally, we discuss disease of our food plants and how models of disease spread are developed to promote better global health. As a postscript to the course we ask the questions, so beloved of modern media, could we become zombies?
9 видео, 1 материал для самостоятельного изучения
- Reading: Module Overview: Global Health
- Видео: SARS - A Modern Epidemic
- Видео: Disease Surveillance - Classical
- Видео: Disease Surveillance - Digital
- Видео: Culture and Health
- Видео: Emerging Disease Issues
- Видео: Crop Diseases and Food Security
- Видео: Global Pattern of Parasite Biodiversity
- Видео: Models of Infectious Diseases
- Видео: Zombies
Оцениваемый: Summative: Global Health
Ask Us Anything Videos
The videos accessible in this module are responses to questions that have been posed in previous sessions of this course. We invite you to look around here as an additional resource to answer questions you might have yourself or explore topics that pique your interest.
36 видео
- Видео: Introductions
- Видео: What Does It Mean to Be Infectious?
- Видео: What is the Impact of Prior Infections on Susceptibility to New Pathogens?
- Видео: What Ended the Plague? What Can We Learn About Pandemics?
- Видео: Can Behavior Contribute to Susceptibility?
- Видео: Marilyn Roosinck and What’s Different about Plant Epidemiology?
- Видео: Can Plants be Vectors of Disease?
- Видео: What are Other Determinants of Susceptibility?
- Видео: Can Pathogens Change Host Function?
- Видео: Immune System Conflict
- Видео: Eric Harvill and What is the Whole Micro-Biome, Pro-Biotic, Good Bacteria Thing?
- Видео: Why Can't Our Antibodies Mutate Like Antigens?
- Видео: How Does Microbiome Exchange Therapy Work?
- Видео: What are the Best Strategies to Combat Multi-Species Infections?
- Видео: How Relevant is the Concept of Critical Community Size?
- Видео: Isabella Catadori and the Translation of Her Lab Work into the Field
- Видео: Examples of Co-Infections and How They Change Epidemiology of Human Infections
- Видео: Super-Shedders v. Super Spreaders and the Pareto Principle
- Видео: The Role of Social Media in Epidemiology and how Information is Disseminated
- Видео: Dr. Vivek Kapur and What Do We Need to Know about Development and Implementation of New Vaccines?
- Видео: Why Don't We Have Vaccines for Everything?
- Видео: Why Don't We Use Targeted Vaccinations?
- Видео: What Are the Benefits of So-Called Gain-of-Function Experiments?
- Видео: Dr. Moriah Szpara and How/Why do viruses like Varicella and Herpes Re-activate Themselves?
- Видео: What are the Challenges to the Eradication of Pathogens and Setting Eradication as a Goal?
- Видео: How Does Stress Affect Susceptibility and the Expression of Disease?
- Видео: Has there been a Collective Change in Human Behavior in Response to Sexually Transmitted Diseases?
- Видео: What can we do to minimize selection for resistance in vectors?
- Видео: Genetic engineering of vectors? pt.1
- Видео: Genetic engineering of vectors? pt.2
- Видео: What is the role of climate change in disease emergence?
- Видео: What can we learn from antibiotic and vaccine use in agriculture?
- Видео: Dr. Craig Cameron and What do We Mean by 'Antivirals?'
- Видео: What is it About Polio?
- Видео: What About the One Health Concept?
- Видео: What is the Next Big Thing?
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Авторы
Университет штата Пенсильвания
Founded in 1855 as Pennsylvania's only land-grant university, The Pennsylvania State University combines academic rigor with a vibrant campus life. A nationally recognized Research-I institution, Penn State teaches students to be leaders with a global perspective.
Supporting not only the citizens of our Commonwealth, Penn State engages in collaborative activities with industrial, educational, and agricultural partners in the United States and abroad to generate, disseminate, integrate, and apply knowledge that is valuable to society.
Рейтинги и отзывы
Very interesting, covering a great diversity of topics inside the epidemics field and easy to follow
it was a pleasure for me to be a participant in that course, it was so useful and tremendous
The instructors state in the beginning, that they put a lot of effort into making this course fun... And it was! The course provides an overview on history of emergence and treatment of infectious diseases as well as developments and future considerations for prevention and treatment. The information is explained very well and supported by very entertaining animations, which help to memorize the course material. The additional readings and videos provided each week were informative and offered increased understanding of each topic. This was the 8th course I completed on Coursera, and eventhough I enjoyed all, this the only one I rated with 5 stars. Enjoy!
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QT
Great course, great professors. Thank you !