Over 500,000 people in the United States and over 8 million people worldwide are dying from cancer every year. As people live longer, the incidence of cancer is rising worldwide, and the disease is expected to strike over 20 million people annually by 2030.
Everyone has been, or will be touched by cancer in some way during their lifetime. Thanks to years of dedication and commitment to research we’ve made enormous advances in the prevention and treatment of cancer, But there is still a lot of work to be done.
In this course, physicians and scientists at the Johns Hopkins School of Medicine explain how cancer spreads or metastasizes. We’ll describe the major theories of metastasis and then describe the biology behind the steps in metastasis. The course also describes the major organs targeted by metastasis and describes how metastases harm the patient.
Understanding Cancer Metastasis
от партнера
Understanding Cancer Metastasis
Johns Hopkins University
Об этом курсе
4.8
Оценки: 479
Приобретаемые навыки
CancerMolecular BiologyCancer BiologyCancer Stem Cells
Программа курса: что вы изучите
Неделя
1History and Overview of Metastasis
In this first module, we'll concentrate on the history and overview of metastasis and give you a flavor of how cancer is defined as well as some of the history surrounding how we began to understand metastasis.
5 видео (всего 18 мин.), 1 тест
5 видео
Introduction to History and Overview of Metastasisмин
History and Overview of Metastasis4мин
History of Metastasis Theory4мин
Introduction to the Sequential Steps of Metastasis5мин
1 практическое упражнение
History and Overview of Metastasis20мин
Primary Tumor Growth and Neoangiogenesis
In this module, we'll focus on uncontrolled cell division, which is a defining property of cancer, as well as mutation and neoangiogenesis and their roles in tumor formation. We'll also take a look at a primary tumor microenvironment and its component cell types.
5 видео (всего 36 мин.), 1 тест
5 видео
Tumor formation: Uncontrolled cell division12мин
The role of mutations in primary tumor formation and evolution11мин
Neoangiogenesis: new blood vessel formation in cancer5мин
The primary tumor microenvironment: what else affects primary tumor growth?6мин
1 практическое упражнение
Primary Tumor Growth and Neoangiogenesis24мин
Неделя
2EMT / Invasion / Intravasation
During this module, we'll turn our attention to the next steps after the initial primary tumor formation, epithelial to mesenchymal transition of cancer cells, and local tumor invasion and intravasation into blood or lymph vessels.
4 видео (всего 18 мин.), 1 тест
4 видео
Epithelial-mesenchymal transition, invasion, and intravision9мин
Local Tumor Invasion4мин
Intravasation2мин
1 практическое упражнение
Invasion and Intravasation14мин
Survival in the Circulation and Extravasation
We'll now take a close look at cancer survival within the circulation, the role of the circulatory system in metastasis, the genetic determinants of metastatic potential, signalling mechanisms, chemokines, the dock and lock hypothesis, and extravasation.
6 видео (всего 31 мин.), 1 тест
6 видео
Glossary of Terms2мин
The Circulation4мин
How cancer cells survive while in circulation4мин
Becoming a circulating tumor cell (CTC) and evading immune detection10мин
Homing to a new site in the body and extravasation8мин
1 практическое упражнение
Survival in the Circulation and Extravasation24мин
Неделя
3Dormancy and Secondary Tumor Growth
In this module, we'll focus on dormancy and secondary tumor growth and how they contribute to the lethality of cancer.
6 видео (всего 31 мин.), 1 тест
6 видео
Metastatic homing5мин
Evidence for cancer dormancy4мин
Cancer dormancy defined8мин
Properties of dormant cancer cells6мин
Secondary outgrowth4мин
1 практическое упражнение
Dormancy and Secondary Tumor Growth20мин
Morbidity and Mortality Associated with Metastasis
In the previous modules, we've looked closely at the sequential steps of metastasis and some of the biology of how metastasis occurs. Now, we'll turn our attention to morbidity and mortality, or in other words, how cancer hurts and kills people.
4 видео (всего 27 мин.), 1 тест
4 видео
Distribution of Metastasis: Where do cancers spread?10мин
Cancer Syndromes14мин
Congratulations1мин
1 практическое упражнение
Morbidity and Mortality Associated with Metastasis20мин
Преподавателей
Kenneth J. Pienta, M.D.
The Donald S. Coffey Professor of UrologyThe James Buchanan Brady Urological Institute
Jelani Zarif
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Sarah Amend
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Haley Axelrod
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
Kenneth Valkenburg
Prostate Cancer ResearcherThe James Buchanan Brady Urological Institute
О Johns Hopkins University
The mission of The Johns Hopkins University is to educate its students and cultivate their capacity for life-long learning, to foster independent and original research, and to bring the benefits of discovery to the world.
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