Об этом курсе
4.6
Оценки: 142
Рецензии: 22
Learn about the technologies underlying experimentation used in systems biology, with particular focus on RNA sequencing, mass spec-based proteomics, flow/mass cytometry and live-cell imaging. A key driver of the systems biology field is the technology allowing us to delve deeper and wider into how cells respond to experimental perturbations. This in turns allows us to build more detailed quantitative models of cellular function, which can give important insight into applications ranging from biotechnology to human disease. This course gives a broad overview of a variety of current experimental techniques used in modern systems biology, with focus on obtaining the quantitative data needed for computational modeling purposes in downstream analyses. We dive deeply into four technologies in particular, mRNA sequencing, mass spectrometry-based proteomics, flow/mass cytometry, and live-cell imaging. These techniques are often used in systems biology and range from genome-wide coverage to single molecule coverage, millions of cells to single cells, and single time points to frequently sampled time courses. We present not only the theoretical background upon which these technologies work, but also enter real wet lab environments to provide instruction on how these techniques are performed in practice, and how resultant data are analyzed for quality and content....
Globe

Только онлайн-курсы

Начните сейчас и учитесь по собственному графику.
Calendar

Гибкие сроки

Назначьте сроки сдачи в соответствии со своим графиком.
Clock

Предполагаемая нагрузка: 6-8 hours/week

Прибл. 19 ч. на завершение
Comment Dots

English

Субтитры: English
Globe

Только онлайн-курсы

Начните сейчас и учитесь по собственному графику.
Calendar

Гибкие сроки

Назначьте сроки сдачи в соответствии со своим графиком.
Clock

Предполагаемая нагрузка: 6-8 hours/week

Прибл. 19 ч. на завершение
Comment Dots

English

Субтитры: English

Программа курса: что вы изучите

1

Раздел
Clock
4 ч. на завершение

Introduction

Description goes here...
Reading
5 видео (всего 144 мин.), 6 материалов для самостоятельного изучения, 1 тест
Video5 видео
Lecture 2 - Biological Model Systems26мин
Lecture 3 - Experimental Perturbations29мин
Lecture 4 - Measuring Nucleic Acids29мин
Lecture 5 - Measuring Protein and Protein States28мин
Reading6 материала для самостоятельного изучения
Lecture Slides10мин
Lecture Slides10мин
Lecture Slide10мин
Lecture Slides10мин
Lecture Slides10мин
Reading List10мин
Quiz1 практическое упражнение
Quiz 140мин

2

Раздел
Clock
3 ч. на завершение

Deep mRNA Sequencing

Description goes here...
Reading
5 видео (всего 93 мин.), 4 материалов для самостоятельного изучения, 1 тест
Video5 видео
Lecture 2 - 2nd and 3rd Generation Sequencing20мин
Lecture 3 - Illumina-Based mRNA Sequencing19мин
Lecture 4 - Lab-Based Video28мин
Lecture 5 - mRNA Sequencing Data Analysis12мин
Reading4 материала для самостоятельного изучения
Lecture Slides10мин
Lecture Slides10мин
Lecture Slides10мин
Reading List10мин
Quiz1 практическое упражнение
Quiz 220мин

3

Раздел
Clock
2 ч. на завершение

Mass Spectrometry-Based Proteomics

Description goes here...
Reading
6 видео (всего 87 мин.), 3 материалов для самостоятельного изучения, 1 тест
Video6 видео
Lecture 2 - Basics of Mass Spectrometry 215мин
Lecture 3 - Quantification in Proteomics15мин
Lecture 4 - Lab-Based Video - Proteomics Day 117мин
Lecture 5 - Lab-Based Video - Proteomics Day 216мин
Lecture 6 - Lab-Based Video - Analysis7мин
Reading3 материала для самостоятельного изучения
Lecture Slides10мин
Lecture Slides10мин
Reading List10мин
Quiz1 практическое упражнение
Quiz 320мин

4

Раздел
Clock
1 ч. на завершение

Midterm Exam

Description goes here...
Reading
1 тест
Quiz1 практическое упражнение
Midterm Exam34мин
4.6
Briefcase

83%

получил значимые преимущества в карьере благодаря этому курсу
Money

50%

стал больше зарабатывать или получил повышение

Лучшие рецензии

автор: FPJun 3rd 2016

Excellent course with a wealth of information about system biology technologies

автор: EMDec 4th 2015

Great course,\n\nRecommended if you are interest in new technologies

Преподаватель

Marc Birtwistle, PhD

Assistant Professor
Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY)

О Icahn School of Medicine at Mount Sinai

The Icahn School of Medicine at Mount Sinai, in New York City is a leader in medical and scientific training and education, biomedical research and patient care....

О специализации ''Systems Biology and Biotechnology'

Design systems-level experiments using appropriate cutting edge techniques, collect big data, and analyze and interpret small and big data sets quantitatively. The Systems Biology Specialization covers the concepts and methodologies used in systems-level analysis of biomedical systems. Successful participants will learn how to use experimental, computational and mathematical methods in systems biology and how to design practical systems-level frameworks to address questions in a variety of biomedical fields. In the final Capstone Project, students will apply the methods they learned in five courses of specialization to work on a research project....
Systems Biology and Biotechnology

Часто задаваемые вопросы

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you enroll in the course, you get access to all of the courses in the Specialization, and you earn a certificate when you complete the work. Your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

Остались вопросы? Посетите Центр поддержки учащихся.