1.2.1 Brain stem

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Advanced Neurobiology I

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Peking University

Advanced Neurobiology I

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Hello everyone! Welcome to advanced neurobiology! Neuroscience is a wonderful branch of science on how our brain perceives the external world, how our brain thinks, how our brain responds to the outside of the world, and how during disease or aging the neuronal connections deteriorate. We’re trying to understand the molecular, cellular nature and the circuitry arrangement of how nervous system works. Through this course, you'll have a comprehensive understanding of basic neuroanatomy, electral signal transduction, movement and several diseases in the nervous system. This advanced neurobiology course is composed of 2 parts (Advanced neurobiology I and Advanced neurobiology II, and the latter will be online later). They are related to each other on the content but separate on scoring and certification, so you can choose either or both. It’s recommended that you take them sequentially and it’s great if you’ve already acquired a basic understanding of biology. Thank you for joining us!

Из урока

Anatomy of the Nervous System

Let's start with a basic introduction of neuroanatomy.

1.2.1 Brain stem9:30

1.2.2 Cranial nerves13:47

1.2.3 Ascending and descending tracts and reticular formation2:47

1.2.5 Reflex and reflex arc3:46

1.2.6 Concepts in the CNS and PNS2:32

1.2.7 Spinal cord8:14

1.2.8 The visceral nervous system12:04

1.2.9 Several pathways of the nervous system5:27

Познакомьтесь с преподавателями

Yan Zhang
Professor
School of Life Sciences, Peking University
Yulong Li
Research Fellow
School of Life Sciences, Peking University

Okay, so let's continue the last time.

We talk about the brain structure last time, and this time we're

just going to talk about the rest part of the brain and the spinal cord.

So, as we said last time, our brain, here, can be divided into

Telencephalon here, the biggest part of our brain and

Diencephalon, in the middle of the brain right here.

And we also talked about Cerebellum here, this part.

Control movement and balance right here.

And this lecture here we're going to

go into the details in brain stems here, this part.

So, Brain stem.

Brain stem consists of three major parts.

One is Midbrain.

It's the structure right here called Midbrain.

Pons, the middle part of Brain stem.

And then here Medulla oblongata,

it's right here.

The main function of our brain stem is to maintain the very basic

activity of our life, including heart beats,

brain stem and digestion.

So let's look at these three major parts of our brain stem one by one.

Medulla oblongata is right here, this part.

So if we look at this structure from the Ventral surface,

we will see a pyramid here.

This look like a pyramid.

And then we have Olive here.

And then we have some sulcus here.

The major sulcus here in medulla is anterolateral sulcus,

this one here, this elongated one here.

And also we have retro Olivary sulcus, this right here, down olivary.

If we have this function in medulla region,

we can have lots of diseases related to misfunction of medulla.

One very famous disease of the misfunction

of medulla is the ALS.

Amyotrophic lateral sclerosis.

And then this famous guy here has this ALS and

then because of the importance or

significance of ALS, recently there's a so-called Ice Bucket Challenge here.

People use this kind

of activity to raise money to try to solve

the mechanism of this disease and then eventually cure this disease.

So medulla is the very lower half of the brain stem and

then link brain stem to the spinal cord and

then it's the link between our central of our brain to the spinal cord.

And then, the upper half of medulla is pons.

And so always refers to a simple as medulla.

And a medulla contains lots of the regulation activity and

regulation center for our activity of our heart,

operation and our digestion.

So upper to the medulla, we have Pons.

Pons is a part, is the middle part of our brains stem.

It's the upper part of medulla.

It's the lower part of the midbrain.

And the pons, sometimes the pons can be called pons

Varolii and this name came from a Italian

neurologist and his last name is Varolio.

So the pons is named after his last name.

There are many nucleus in our pons.

A number of cranial nerve nucleus are localized in pons and

then these cranial nerve nucleus include

trigeminal nerve sensory nucleus.

And then there's motor nucleus for trigeminal nerve.

And then there's abducens nucleus.

There's facial nerve nucleus in the pons area.

And in the pons, the medulla connects the higher level

of the brain to the spinal cord and it's responsible for

several functions of automoto nervous system.

And includes the blood and the activity

of our blood including the acidity of the blood,

such if the blood is considered too acidic by the medulla,

and there are some signals can send back to the muscle tissue in our lungs

and the muscles in our lungs to increase the contraction

of the lungs and then can uptake more oxygen.

And also in the pons we have a center called

cardiac center, which controls the heartbeat.

And also we have the control center for our blood pressure,

as well as some reflexes in the pons area.

So upper to the pons area we have Midbrain here.

And then, if we look at Midbrain from the dorsal region we can see superior

colliculus here, these two parts here.

And we have inferior colliculus here, down here.

The lower parts here.

And then for the superior colliculus is the relay center for

our visual reflexes and our visual information,

and for inferior colliculus, it's the relay center for our auditory pathways.

So the visual information get into the central system

through the superior colliculus and

then the auditory information get into the brains through the inferior colliculus.

Also in the midbrain region, we have our ventricle system as well.

Last time we mentioned two lateral ventricle system.

So from the ventricle system,

we know CSF is pretty used up by our two lateral ventricle system.

And then the CSF can go through within the skull and our synaptic system.

And then now in the midbrain we have the fourth ventricle.

And then the fourth ventricle located right here.

This triangle shaped structure is the fourth ventricle.

And then here is the two lateral ventricle.

And then this is the third ventricle.

And then, this is the fourth ventricle system here.

And then sometimes the two lateral ventricle systems can be called the first

and the second ventricle system because from the name, here is the third and

here is the fourth, so where is the first and the second one?

So the two lateral ventricles sometimes can be named as the first and

the second ventricle.

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