Об этом курсе
Precision medicine has the potential to change fundamentally how health care is practiced, but requires a health care workforce that understands the complexities of this field. One important component of Precision Medicine is the use of an individual’s genomic information to offer targeted treatment, tailored to the individual. Our course aims to provide participants with some baseline knowledge of genomics, an overview of the clinical applications of genomic medicine, the skills to evaluate the clinical validity and utility of new tests, and an appreciation of the associated ethical and social issues inherent in this field. The course is geared toward practicing health care providers, although it should be accessible to anyone with a background in the biological sciences and a basic understanding of genetics. It is designed to be succinct and clinically-focused, offering both conceptual and practical information about real-world applications of genomics. Two lessons offer a basic primer on molecular genomics relevant to the individual patient as well as to patient populations. The remaining five lessons focus on five applications of genomics and present the material as case studies, highlighting the strengths, limitations, and issues that arise in the use of each test.
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Только онлайн-курсы

Начните сейчас и учитесь по собственному графику.
Intermediate Level

Промежуточный уровень

Clock

Approx. 14 hours to complete

Предполагаемая нагрузка: Approximately two hours per week: Lectures: 60 min., Assessments: 30 min., Reading: 30 min.
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English

Субтитры: English

Приобретаемые навыки

GenomicsGeneticsPharmacogeneticsLinkage Analysis
Globe

Только онлайн-курсы

Начните сейчас и учитесь по собственному графику.
Intermediate Level

Промежуточный уровень

Clock

Approx. 14 hours to complete

Предполагаемая нагрузка: Approximately two hours per week: Lectures: 60 min., Assessments: 30 min., Reading: 30 min.
Comment Dots

English

Субтитры: English

Syllabus - What you will learn from this course

1

Section
Clock
2 hours to complete

Week 1

This week you will learn foundational concepts about the structure and function of the human genome and different types of genetic and non-genetic variation that occur....
Reading
5 videos (Total 61 min), 1 reading, 1 quiz
Video5 videos
Week 1 - Module 2: Human Genetic Variation — Structural Variants 11m
Week 1 - Module 3: Human Genetic Variation — Single Nucleotide Variants14m
Week 1 - Module 4: Consequences of Single Nucleotide Variants in Genes 6m
Week 1 - Module 5: Architecture of Human Genetic Variation 14m
Reading1 readings
Suggested Readings10m
Quiz1 practice exercises
Week 1 Quiz20m

2

Section
Clock
2 hours to complete

Week 2

This week, Drs. Nussbaum and Norton will describe the use of genomics in the reproductive setting: carrier testing, non-invasive prenatal screening, prenatal diagnosis of Mendelian diseases, and newborn screening....
Reading
5 videos (Total 85 min), 1 quiz
Video5 videos
Week 2 - Module 2: Genetic Testing for Mendelian Diseases 17m
Week 2 - Module 3: Newborn Screening 11m
Week 2 - Module 4: Carrier Testing 17m
Week 2 - Supplemental Video - Prenatal Diagnosis 21m
Quiz1 practice exercises
Week 2 Quiz20m

3

Section
Clock
1 hour to complete

Week 3

This week Dr. Nussbaum will review the use of next-generation sequencing for solving diagnostic dilemmas....
Reading
4 videos (Total 50 min), 1 quiz
Video4 videos
Week 3 - Module 2: Clinical Interpretation of Variants 17m
Week 3 - Module 3: Using NGS for Diagnostic Dilemmas 11m
Week 3 - Module 4: Practical Aspects 8m
Quiz1 practice exercises
Week 3 Quiz20m

4

Section
Clock
1 hour to complete

Week 4

This week we will explore the genetics of common, complex diseases and the population genetics methods used to uncover genetic associations....
Reading
5 videos (Total 48 min), 1 quiz
Video5 videos
Week 4 - Module 2: Genome-Wide Association Study Methods 13m
Week 4 - Module 3: Genome-Wide Association Study — Analysis 7m
Week 4 - Module 4: Genome-Wide Association Study — Interpretation 11m
Week 4 - Module 5: What Do We Know About the Genetics of Common, Complex Diseases? 4m
Quiz1 practice exercises
Week 4 Quiz20m

5

Section
Clock
1 hour to complete

Week 5

This week Dr. Mendelsohn joins me to roll play some scenarios to teach you about predictive tests for common, complex diseases and direct-to-consumer testing. ...
Reading
4 videos (Total 56 min), 1 quiz
Video4 videos
Week 5 - Module 2: Case Scenario - Coronary Artery Disease Example 15m
Week 5 - Module 3: Case Scenario - Diabetes Example 12m
Week 5 - Module 4: Case Scenario - Alzheimer's Example 10m
Quiz1 practice exercises
Week 5 Quiz20m

6

Section
Clock
1 hour to complete

Week 6

This week we discuss pharmacogenomic testing for drug selection, dosing and predicting adverse effects of commonly prescribed drugs....
Reading
4 videos (Total 55 min), 1 quiz
Video4 videos
Week 6 - Module 2: What Pharmacogenic Tests are Available? 9m
Week 6 - Module 3: Is My Patient a Candidate for Pharmacogenomic Testing? 19m
Week 6 - Module 4: Where to Get Testing Done and How to Interpret the Results? 11m
Quiz1 practice exercises
Week 6 Quiz20m

7

Section
Clock
1 hour to complete

Week 7

Our final lecture explores tumor profiling for targeting cancer treatment and the use of blood-based gene expression profiles in cancer prognosis....
Reading
4 videos (Total 66 min), 1 quiz
Video4 videos
Module 2: Hereditary Cancer 15m
Module 3: Tumor Genetic Landscape12m
Module 4: Clinical Applications — Prognosis and Treatment Response20m
Quiz1 practice exercises
Week 7 Quiz20m
4.8
Direction Signs

33%

started a new career after completing these courses
Briefcase

83%

got a tangible career benefit from this course

Top Reviews

By TGFeb 10th 2018

Really nice and designed to clinical practice. I believe this course will help me a lot in my practice. Really well-designed, short lectures and interesting examples. I really appreciate this course!

By BLSep 4th 2017

Being myself working for 2 years as a genetic data analyst, I still found this course interesting and learnt new things. Thanks to Coursera and Professors as well as University of Cali, SF.

Instructors

Avatar

Jeanette McCarthy, MPH, PhD

Adjunct Associate Professor
Avatar

Robert L. Nussbaum, MD

Chief and Professor of Medicine

About University of California, San Francisco

The University of California, San Francisco, is dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. UC San Francisco is the only campus in the University of California system dedicated exclusively to the health sciences. UCSF's innovative, collaborative approaches for health care, research and education span disciplines across the health sciences and make it a world leader in scientific discovery and its translation into improved health....

Frequently Asked Questions

  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • If you pay for this course, you will have access to all of the features and content you need to earn a Course Certificate. If you complete the course successfully, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. Note that the Course Certificate does not represent official academic credit from the partner institution offering the course.

  • Yes! Coursera provides financial aid to learners who would like to complete a course but cannot afford the course fee. To apply for aid, select "Learn more and apply" in the Financial Aid section below the "Enroll" button. You'll be prompted to complete a simple application; no other paperwork is required.

  • No, we are unable to offer CME or continuing education credits for this course.

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