Об этом курсе
4.5
Оценки: 31
Рецензии: 7
Most people know that electrically active cells in nerves, in the heart and in the brain generate electrical currents, and that somehow these result in measurements we all have heard about, such as the electrocardiogram. But how? That is, what is it that happens within the electrically active tissue that leads to the creation of currents and voltages in their surroundings that reflect the excitation sequences timing, and condition of the underlying tissue. This course explores that topic. Rather than being a primer on how to interpret waveforms of any kind in terms of normality or disease, the goal here is to provide insight into how the mechanism of origin actually works, and to do so with simple examples that are readily pictured with simple sketches and one’s imagination, and then moving forward into comparison with experiments and finding outcomes quantitatively....
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Intermediate Level

Промежуточный уровень

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Предполагаемая нагрузка: 7 weeks of study, 1-3 hours/week

Прибл. 6 ч. на завершение
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Только онлайн-курсы

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Calendar

Гибкие сроки

Назначьте сроки сдачи в соответствии со своим графиком.
Intermediate Level

Промежуточный уровень

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Предполагаемая нагрузка: 7 weeks of study, 1-3 hours/week

Прибл. 6 ч. на завершение
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Программа курса: что вы изучите

1

Раздел
Clock
1 ч. на завершение

Week 1

A brief history of extracellular measurements, and an example of such a recording. The goal is to understand the amplitudes and time variation of such measurements, as well as learn about some interesting and useful historical events....
Reading
3 видео (всего 20 мин.), 3 материалов для самостоятельного изучения, 1 тест
Video3 видео
Welcome7мин
The First Extracellular Measurements5мин
Observing Wave Forms Between Human Hands7мин
Reading3 материала для самостоятельного изучения
Course Overview10мин
Assessments, Grading and Certificates10мин
Week 1 Slides10мин
Quiz1 практическое упражнение
120мин

2

Раздел
Clock
2 ч. на завершение

Week 2

A presentation of the cylindrical fiber model of a nerve. The goal is to see how this geometrically simple model of a nerve actually is sufficient to explain complex bioelectric events within and around electrically active tissue. One learns that currents are driven forward by voltages across cell membranes,. Current loops are created, with some parts of the current loop inside and other parts outside the active cells. Electrical potentials are created by the current loops, and are positive when these are approaching, negative when they are receding. In so doing they form the basis of all extracellular wave forms....
Reading
9 видео (всего 44 мин.), 3 материалов для самостоятельного изучения, 1 тест
Video9 видео
Geometry6мин
Left or right side stimulation5мин
Simultaneous stimulation model2мин
Definitions and questions6мин
Origin in the membrane6мин
Big loops as well as small4мин
Approaching wave forms5мин
Departing wave forms3мин
Observations4мин
Reading3 материала для самостоятельного изучения
Cylinderical Fiber Model Slides9мин
Current Loops Slides10мин
Current Loops and the Extracellular Waveforms Slides10мин
Quiz1 практическое упражнение
224мин

3

Раздел
Clock
1 ч. на завершение

Week 3

Notable and useful aspects of extracellular wave forms are their changes in shape. What causes such changes? Two illuminating examples are studied, one that does not, and then another that does....
Reading
7 видео (всего 33 мин.), 3 материалов для самостоятельного изучения, 1 тест
Video7 видео
Vm and current inside3мин
Vm patterns3мин
Current loops3мин
Experimental setup, cardiac Purkinje6мин
Stimulation at the left or right3мин
Stimulation at both ends, collision5мин
Reading3 материала для самостоятельного изучения
When do Wave Shapes Change? Slides10мин
Simultaneous Left and Right Stimulation Slides10мин
Experimental Data Slides10мин
Quiz1 практическое упражнение
324мин

4

Раздел
Clock
1 ч. на завершение

Week 4

Weeks 1 to 3 present some intriguing concepts and explain them with drawings and sketches. Do the wave forms so drawn have any connection with real tissue? Indeed they do. The goal of this week is to examine some specific experimental wave forms that were measured in cardiac Punkinje fibers, and to compare them those anticipated in earlier weeks.Week 4 is the end of the standard course. The remaining weeks are for honors study....
Reading
4 видео (всего 17 мин.), 1 материал для самостоятельного изучения, 1 тест
Video4 видео
Two-fiber model, asynchronous2мин
Experimental findings6мин
Multiphasic summary3мин
Reading1 материал для самостоятельного изучения
Multiphasic Recordings Slides10мин
Quiz1 практическое упражнение
424мин
4.5

Лучшие рецензии

автор: AJApr 15th 2018

Great follow up course to the previous within the installment regarding bioelectricity. Taught me quite a lot and am looking forward to further releases to the series if they are in the works.

автор: PWMar 8th 2017

Having been out school for over 30 years this was a very challenging but rewarding course for myself. I'm glad i took it

Преподаватель

Dr. Roger Barr

Anderson-Rupp Professor of Biomedical Engineering and Associate Professor of Pediatrics
Biomedical Engineering, Pediatrics

О Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

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  • Once you enroll for a Certificate, you’ll have access to all videos, quizzes, and programming assignments (if applicable). Peer review assignments can only be submitted and reviewed once your session has begun. If you choose to explore the course without purchasing, you may not be able to access certain assignments.

  • When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

  • No. Completion of a Coursera course does not earn you academic credit from Duke; therefore, Duke is not able to provide you with a university transcript. However, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.

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