Об этом курсе
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Рецензии: 13
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Прибл. 9 часа на выполнение

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Английский

Субтитры: Английский
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Прибл. 9 часа на выполнение

Предполагаемая нагрузка: 6 hours/week...
Доступные языки

Английский

Субтитры: Английский

Программа курса: что вы изучите

Неделя
1
Часов на завершение
3 ч. на завершение

Cracking the Genetic Code

In this module, we'll explore the molecular structure of DNA. What is DNA? What are the basic building blocks of DNA? Where can you find DNA within a cell? We'll learn about how James Watson and Francis Crick were able to solve the riddle of the molecular structure of DNA by building on the work of other scientists. Their groundbreaking discovery revealed that four nucleobases (adenine, thymine, cytosine, and guanine) combine with sugar and phosphate molecules to form the familiar double helix of DNA. We'll take a look at how the molecular structure of DNA regulates its functions; for example, how the chemical bonds (covalent and noncovalent) between these molecules allow DNA to "unzip" during replication. Then we'll take a look at how you manage to fit over three billion base pairs into each of your cells. (Here's a hint: Histones, nucleosomes, and chromosomes would be great at packing for a trip!)...
Reading
7 видео ((всего 45 мин.)), 4 материалов для самостоятельного изучения, 6 тестов
Video7 видео
How to Speak DNA4мин
Cracking the Genetic Code4мин
The Building Blocks of DNA5мин
Packing it all in!6мин
Summing Up1мин
The Double Helix16мин
Reading4 материала для самостоятельного изучения
Timeline of DNA Discoveries10мин
Behind the Picture: Photo 51 (interview)10мин
(Not Really) The Last Word about DNA (video)10мин
Biochemistry: The Operating System of Life (video)10мин
Quiz6 практического упражнения
How to Speak DNA6мин
Cracking the Genetic Code6мин
The Building Blocks of DNA8мин
Packing it all in!6мин
DNA Word Search2мин
Cracking the Genetic Code22мин
Неделя
2
Часов на завершение
3 ч. на завершение

Getting the Message Across: Transcription, Translation, and Replication

We've all heard DNA described as "the blueprint of life," but what does that actually mean? Each one of the approximately 20,000 genes in our bodies contains the instructions for building a protein. In this module, we'll explain how RNA copies the genetic information contained in our genes and uses this information to assemble amino acids into proteins. Scientists call this concept "Central Dogma": DNA makes RNA and RNA makes protein. We'll also explore how we transmit genetic information from one cell to another -- and what happens when things go wrong. Along the way, we'll learn about techniques (such as polymerase chain reactions and gel electrophoresis) that forensic scientists use in DNA fingerprinting. Join us this week for murder and mayhem in the lab!...
Reading
8 видео ((всего 52 мин.)), 4 материалов для самостоятельного изучения, 9 тестов
Video8 видео
Stop copying me! DNA Replication6мин
Central Dogma, Part I: Transcription8мин
Central Dogma, Part II: Translation7мин
Practical DNA: Polymerase Chain Reaction (PCR)8мин
Practical DNA: Gel Electrophoresis7мин
Summing Up3мин
DNA Replication3мин
Reading4 материала для самостоятельного изучения
The Case of the Silenced Scientist10мин
Labster: Crime Scene Investigation10мин
TED Talk: Drew Barry - Animations of Unseeable Biology (video)10мин
Protein Data Bank10мин
Quiz9 практического упражнения
The Scene of the Crime4мин
Stop copying me! DNA Replication4мин
Central Dogma, Pt 1: Transcription8мин
Central Dogma, Pt 2: Translation6мин
Decipher the Secret Message2мин
Breaking the Code (aka Game of Codons)4мин
Polymerase Chain Reaction (PCR)4мин
Gel Electrophoresis6мин
Getting the Message Across16мин
Неделя
3
Часов на завершение
3 ч. на завершение

Manipulating DNA

In this module, we'll explore the techniques scientists use to manipulate DNA. Genetic engineering has allowed us to increase crop yields, diagnose illnesses, develop vaccines, and manufacture insulin. By carefully selecting a pair of molecular scissors (restriction enzymes), scientists are able to isolate a gene of interest and insert it into plasmid DNA, turning a common bacteria (E. coli) into a molecular copying machine. This week, we'll learn that mutations are genetic errors, but that not all mutations are necessarily bad — in fact, some mutations confer a selective advantage that protects against disease. We'll explain what genetically modified organisms are (and what they are not) and weigh in on the heated debates about the ethics and safety of GMOs in popular media....
Reading
8 видео ((всего 46 мин.)), 5 материалов для самостоятельного изучения, 7 тестов
Video8 видео
Slice and Dice: Restriction Enzymes10мин
Lights, Camera, Transformations6мин
Mutations, Mutations, Mutations!6мин
From Bananas to Papayas: Genetically Modified Organisms (GMOs)9мин
Summing Up4мин
Genetic Engineering1мин
Sickle Cell Anemia59s
Reading5 материала для самостоятельного изучения
Labster: Molecular Cloning Simulation10мин
Creating Dolly (video)10мин
Genetic Engineering and Working with DNA (video)10мин
How did they make insulin from recombinant DNA? (article)10мин
Massive Review Reveals Consensus on GMO Safety (article)10мин
Quiz7 практического упражнения
Freaky Fruit: Manipulating DNA6мин
Slice and Dice: Restriction Enzymes6мин
Lights, Camera, Transformations6мин
Mutations, mutations, mutations6мин
From Papayas to Bananas: Genetically Modified Organisms (GMOs)6мин
Help Felicia design a blue tomato!8мин
Manipulating DNA16мин
Неделя
4
Часов на завершение
3 ч. на завершение

DNA and Me

What does your DNA say about you? You may have heard that you share 99% of your genetic material with everyone else on the planet. That's true, but this week we're going to take a look at the less than 1% that makes you unique. We'll kick off by discussing the Human Genome Project, the massive scientific collaboration that mapped out the sequence of all our genetic material. The technologies developed while mapping out the human genome ushered in a new age in DNA research. Now, genome-wide association studies can analyze massive amounts of data, searching for genetic variations that are associated with particular diseases. Pharmacogenomics may help determine which drugs are likely be most effective for you. Genetic genealogy tests (such as Ancestry DNA, 23 and Me, and Family Tree DNA) will allow you to trace random mutations in your DNA that can provide clues to your ethnic heritage. As an added bonus, we'll discuss whether it would be possible to revive extinct species by studying ancient DNA....
Reading
9 видео ((всего 45 мин.)), 7 материалов для самостоятельного изучения, 6 тестов
Video9 видео
Sanger Sequencing3мин
The Human Genome Project5мин
Mammoths, Mummies, and Microbes: Ancient DNA10мин
Me and My Family Tree8мин
DNA and My Health5мин
That's a wrap!5мин
Sanger Sequencing51s
Human Genome Sequencing1мин
Reading7 материала для самостоятельного изучения
Labster: Next Generation Sequencing Simulation10мин
Cracking the Code of Life (video)10мин
Iceman Murder Mystery (video)10мин
Personal DNA Testing (video)10мин
My Career in Genomics: Antibiotic Resistance (video)10мин
My Career in Genomics: Cancer Biology (video)10мин
My Career in Genomics: Evolution (video)10мин
Quiz6 практического упражнения
DNA: Our Genetic Blueprint2мин
Sanger Sequencing8мин
Me and My Family Tree4мин
DNA and My Health2мин
DNA and Me18мин
Scientists Complete First Chapter of Book of Life With Decoding of First Human Chromosome (article)4мин

Преподавателя

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Caitlin Mullarkey

Assistant Professor
Health Sciences
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Felicia Vulcu

Assistant Professor
Biochemistry and Biomedical Sciences

О McMaster University

Founded in 1887, McMaster University is committed to creativity, innovation, and excellence by inspiring critical thinking, personal growth, and a passion for learning. Ranked amongst the Top 100 universities in the world, McMaster pioneered a learner-centred, problem-based, interdisciplinary approach to learning that is now known worldwide as the “McMaster Model”. ...

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