Об этом курсе
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Оценки: 41
Рецензии: 6
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Прибл. 19 часа на выполнение

Предполагаемая нагрузка: 6 weeks of study, 3-5 hours a week...
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Английский

Субтитры: Английский
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Часов на завершение

Прибл. 19 часа на выполнение

Предполагаемая нагрузка: 6 weeks of study, 3-5 hours a week...
Доступные языки

Английский

Субтитры: Английский

Программа курса: что вы изучите

Неделя
1
Часов на завершение
3 ч. на завершение

Introduction. Human genome

This week you will learn about human genome organisation. This week is very important as all this knowledge will form a basis for all of the subsequent weeks of the course. Michel Georges will tell you about the structural organisation of the human genome, the mechanisms contributing to the genome variability, the main types of genetic variation (SNPs, CNVs, aneuploidy, etc.), and differences between alleles and genotypes. You will also learn the techniques used to detect different types of variations in human genome and you will find out how we can follow the inheritance of genetic material through generations. ...
Reading
7 видео ((всего 54 мин.)), 9 материалов для самостоятельного изучения, 9 тестов
Video7 видео
Course Introduction1мин
Anatomy of the Human Genome13мин
Identifying Functionally Important Elements in the Human Reference Genome12мин
Genetic Polymorphism11мин
Interrogating Genetic Variation10мин
Week 1 Conclusion2мин
Reading9 материала для самостоятельного изучения
Meet your Educators and Fellow Learners10мин
Course Navigation10мин
Typos in videos10мин
Recommended Pre-reading10мин
The Human Genome Project30мин
Recommended Pre-reading10мин
Recommended Pre-reading10мин
Recommended Pre-reading10мин
Glossary Week 110мин
Quiz9 практического упражнения
Pre-lecture Questions6мин
Practice Quiz2мин
Pre-lecture Questions4мин
Practice Quiz2мин
Pre-lecture Questions4мин
Practice Quiz4мин
Pre-lecture Questions6мин
Practice Quiz2мин
Introduction. Human Genome8мин
Неделя
2
Часов на завершение
4 ч. на завершение

Populational genetics

During this week, Yurii Aulchenko will teach you the basics of population and quantitative genetics. Population genetics is a branch of genetics that deals with genetic variation among individuals in a population. "Nothing in Biology Makes Sense Except in the Light of Evolution" is a quotation from a 1973 essay by the evolutionary biologist Theodosius Dobzhansky. The fundamental importance of population genetics lies in the insights it provides into the mechanisms of evolution, thus allowing geneticists to better understand the drivers behind the organization and functioning of human genomes. You will learn about such phenomena as population structure, selection and genetic drift. You will also learn about quantitative genetics, which studies how the genes and environment control variations in complex phenotypes....
Reading
7 видео ((всего 59 мин.)), 13 материалов для самостоятельного изучения, 13 тестов
Video7 видео
Hardy-Weinberg Equilibrium8мин
Linkage Disequilibrium8мин
Natural Selection11мин
Genetic Drift9мин
Genetic Structure12мин
Week 2 Conclusion2мин
Reading13 материала для самостоятельного изучения
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Glossary Week 210мин
Quiz13 практического упражнения
Pre-lecture Questions4мин
Practice Quiz4мин
Pre-lecture Questions6мин
Practice Quiz4мин
Pre-lecture Questions4мин
Practice Quiz4мин
Pre-lecture Questions4мин
Practice Quiz2мин
Pre-lecture Questions4мин
Practice Quiz4мин
Pre-lecture Questions2мин
Practice Quiz4мин
Populational Genetics14мин
Неделя
3
Часов на завершение
3 ч. на завершение

Mendelian disorders

Mendelian or monogenic disorders are the kind of genetic disorders in humans that arise from a mutation in a single gene. These disorders run in families and can be autosomal or sex-linked depending whether the affected gene is located on autosomes or sex chromosomes, and they can also be dominant or recessive depending if one or two alleles are necessary to develop the disorder. The name “Mendelian” is used because these diseases follow simple monogenic patterns of inheritance, similar to these first studied by Gregor Mendel in pea plants. There are an estimated 8000 rare Mendelian diseases. Although each of them are very rare, collectively they affect millions of individuals world-wide. How can we find the variants and genes that are responsible for the development of these diseases? You will learn about “linkage analysis” – a technique that has been previously used for this purpose. You will also learn about Next-generation sequencing (NGS) technologies that have revolutionized the studies of Mendelian diseases in recent years. ...
Reading
6 видео ((всего 51 мин.)), 10 материалов для самостоятельного изучения, 11 тестов
Video6 видео
Linkage Analysis. Family Studies11мин
NGS for Studying Monogenic Disorders — Part I7мин
NGS for Studying Monogenic Disorders — Part II10мин
NGS for Studying Monogenic Disorders — Part III11мин
Week 3 Conclusion1мин
Reading10 материала для самостоятельного изучения
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Mendelian disorders: discussion10мин
Glossary Week 310мин
Quiz11 практического упражнения
Pre-lecture Questions2мин
Practice Quiz2мин
Pre-lecture Questions2мин
Practice Quiz2мин
Pre-lecture Questions2мин
Practice Quiz2мин
Pre-lecture Questions4мин
Practice Quiz2мин
Pre-lecture Questions2мин
Practice Quiz2мин
Mendelian Disorders10мин
Неделя
4
Часов на завершение
6 ч. на завершение

Complex disorders

In contrast to Mendelian disorders that are controlled by a mutation in one gene, the multifactorial disorders are more complex, thus the name. These disorders are affected by an interplay of many genetic and environmental factors and also by a chance. Most of the human disorders, including prevalent types of diabetes, cardiovascular diseases, different cancers, are of such type. Although these disorders often cluster in families, they do not segregate in ways that are consistent with simple Mendelian inheritance. The methods used to find variants responsible for Mendelian disorders are not applicable for complex ones. Genome-wide association studies, or “GWAS” is a current method of choice to pinpoint the genetic variation predisposing to complex disorders. Yurii Aulchenko together with Lennart Karssen will tell you about this method and discuss its advantages and limitations. ...
Reading
10 видео ((всего 88 мин.)), 18 материалов для самостоятельного изучения, 19 тестов
Video10 видео
Introduction to Genome-Wide Association Studies. Historical Overview12мин
GWAS Nowadays. Imputations10мин
4.4. Analysis of Directly Genotyped and Imputed data. Significance of GWAS11мин
4.5. Population Stratification and its Consequences10мин
4.6. Analysis of Genetically Structured Populations9мин
4.7. Meta-analysis of GWAS Results: Theory and Background6мин
4.8. Quality Control of GWAS Array Data10мин
4.9. Meta-analysis of GWAS Results: Practical Details8мин
Week 4 Conclusion2мин
Reading18 материала для самостоятельного изучения
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Recommended Pre-reading10мин
Additional Materials10мин
Additional Materials10мин
Glossary Week 410мин
Quiz19 практического упражнения
Pre-lecture Questions4мин
Practice Quiz4мин
Pre-lecture Questions2мин
Practice Quiz6мин
Pre-lecture Questions2мин
Practice Quiz2мин
Pre-lecture Questions4мин
Post-lecture Questions4мин
Pre-lecture Questions2мин
Post-lecture Questions4мин
Pre-lecture Questions4мин
Post-lecture Questions6мин
Pre-lecture Questions2мин
Post-lecture Questions4мин
Pre-lecture Questions2мин
Post-lecture Questions2мин
Pre-lecture Questions2мин
Quiz4мин
Complex disorders26мин
4.7
Рецензии: 6Chevron Right
Продвижение по карьерной лестнице

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Лучшие рецензии

автор: FLSep 27th 2018

Highly recommended!\n\nAn interesting, up-to-date course with eye-catching and well designed videos.

автор: JQDec 30th 2017

Fun and interesting course. Great review of material I had forgotten, sadly.

Преподавателя

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Marianna Bevova

PhD, Director of GIGA Doctoral School
University of Liège (GIGA)
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Michel Georges

PhD, Professor, GIGA Research Director
University of Liège
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Gert Matthijs

PhD, Professor
Center for Human Genetics, University of Leuven
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Lennart Karssen

PhD, Owner and Chief Computational Scientist
PolyOmica
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Natalia Aulchenko

M.Sc., Project manager
Theoretical and Applied Functional Genomics Laboratory
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Yakov Tsepilov

PhD, Senior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Sodbo Sharapov

M.Sc, Junior Researcher
Theoretical and Applied Functional Genomics Laboratory
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Alexander Tashkeev

Skolkovo Institute of Science and Technology (Skoltech), Junior Researcher
Laboratory of Computational and Structural Transcriptomics
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Yurii Aulchenko

PhD, Professor, Head of Theoretical and Applied Functional Genomics Laboratory
Theoretical and Applied Functional Genomics Laboratory

О Novosibirsk State University

Novosibirsk State University (NSU) is a research university located in Novosibirsk Akademgorodok, the world-famous scientific center in Siberia. 80% of NSU teachers are active researchers affiliated with the Russian Academy of Sciences; therefore education is closely linked to world-class science: our students get first-hand knowledge about scientific discoveries before they are published. Nearly 6000 students (including international students from 37 countries) are enrolled at undergraduate and graduate programs offered by 13 departments. The leading areas of NSU expertise are natural sciences, life sciences, physics, math, IT, and more....

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