Об этом курсе: This course is geared towards starting undergraduate students. A solid background in biology will be helpful but not absolutely essential. The material will be of interest to those who are pursuing a career in any of the life sciences as well as anyone who has run up against their biological clock.
Автор: Ludwig-Maximilians-Universität München (LMU)
Преподаватели: Martha Merrow, Professor
Medical PsychologyПреподаватели: Till Roenneberg, Professor
Medical Psychology
| Язык | Английский |
| Как пройти курс | Чтобы пройти курс, выполните все оцениваемые задания. |
Программа курса
НЕДЕЛЯ 1
WEEK 1
Introduction to 'chronobiology'. What sorts of rhythms are observed in nature? Most of the lecture will be spent on describing daily or circadian rhythms in organisms from bacteria to man.
9 видео, 1 материал для самостоятельного изучения
- Видео: 1.1 The Family of Biological Rhythms
- Видео: 1.2 The Circa-Rhythms
- Видео: 1.3 Spatial and Temporal Niches
- Видео: 1.4 The Case of Gonyaulax polyedra
- Видео: 1.5 Introduction to the Second Half of Lecture 1
- Видео: 1.6 Circadian Rhythms in Mammals
- Видео: 1.7 Circadian Clocks in Flies, Plants and Fungi
- Видео: 1.8 Wrap up for Lecture 1
- Reading: Literature suggestion
Оцениваемый: Lecture 1, Introduction, first half.
Оцениваемый: Lecture 1, Introduction, second half.
НЕДЕЛЯ 2
WEEK 2
Circadian rhythms synchronise to the 24-hour environment. Organisms use specialised photoreceptors to do this and they display characteristic properties in this process. We experience this active synchronisation process for example when we suffer from jet lag!
5 видео, 3 материала для самостоятельного изучения
- Видео: 2.1 Pittendrigh´s generalisations 1-9
- Видео: 2.2 Pittendrigh´s generalisations 10 and 11
- Видео: 2.3 Pittendrigh´s generalisations 12-16 and entrainment
- Видео: 2.4 Wrap-up for Lecture 2
- Reading: Literature suggestion
- Reading: Translation of de Mairan's botanical observation
- Reading: Obituary Jürgen Aschoff
Оцениваемый: Formalisms
НЕДЕЛЯ 3
WEEK 3
We will discuss the elaborate molecular mechanisms that allow circadian clocks to produce their daily rhythms and to synchronise them to its environment. We will compare these mechanisms in a wide range of organisms.
8 видео, 1 материал для самостоятельного изучения
- Видео: 3.1 The first clock gene
- Видео: 3.2 The negative feedback hypothesis
- Видео: 3.3 More clock genes -many more!
- Видео: 3.4 Post transcriptional mechanisms and the clock
- Видео: 3.5 Indications of a non-transcriptional clock
- Видео: 3.6 Zeitgebers and the molecular clockwork
- Видео: 3.7 Wrap-up to Lecture 3
- Reading: Literature suggestion
Оцениваемый: Lecture 3 Molecular mechanisms
НЕДЕЛЯ 4
WEEK 4
Circadian clocks serve to orchestrate physiology and metabolism in a coordinated way over the course of the day. Therefore, practically all processes in an organism are regulated outputs of the clock. We'll discuss examples of these processes and ideas about how this circadian regulation works.
8 видео, 1 материал для самостоятельного изучения
- Видео: 4.1 Clock control: which processes in humans and how to measure them?
- Видео: 4.2 Schwänzeltanz
- Видео: 4.3 The SCN regulates the timing of physiology and behaviour
- Видео: 4.4 Clock controlled genes (ccg´s)
- Видео: 4.5 Clock regulation of behaviour: genetic mechanisms
- Видео: 4.6 Clock regulation of other major regulatory systems
- Видео: 4.7 Wrap-Up to Lecture 4
- Reading: Literature suggestion
Оцениваемый: Lecture 4: Clock control
НЕДЕЛЯ 5
WEEK 5
With the appreciation of the clock’s global control, we proceed to discussing how much this temporal programme controls our lives from birth to death and how much we mistreat the circadian clock in modern life.
6 видео, 1 материал для самостоятельного изучения
- Видео: 5.1 Chronotypes
- Видео: 5.2 What makes up Chronotypes?
- Видео: 5.3 Linking chronotype and light entrainment
- Видео: 5.4 How modern life styles affect sleep
- Видео: 5.5 Wrap-up to Lecture 5
- Reading: The link to the MCTQ
Оцениваемый: Human
НЕДЕЛЯ 6
WEEK 6
Finally, we will look at the clock’s relationship to pathology. What are the consequences of living against the clock, what happens if the clock ‘breaks’, and how can we use our knowledge about the circadian system in medical diagnosis and therapy.
11 видео, 1 тренировочный тест
- Видео: 6.1 What is normal and what not and why?
- Видео: 6.2 The consequences of living against the clock
- Видео: 6.3 Circadian changes and Pathologies - comorbidities or causal factors
- Видео: 6.4 Introduction to the Second Half of Lecture 6
- Видео: 6.5 Clock genes that can really mess up the timing of sleep
- Видео: 6.6 The clock gene mutant mice are sick
- Видео: 6.7 Chronopharmacology and chronochemotherapy
- Видео: 6.8 The circadian clock is a fitness characteristic
- Видео: 6.9 Wrap-up to Lecture 6
- Видео: 6.10 Farewell from your CircaClock Team
- Practice Quiz: Final Exam "Circaclock"
- Peer Review: Peer-Reviewed Assignment
Оцениваемый: Pathology
Оцениваемый: Lecture 6. Clock and pathologies
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Авторы
Ludwig-Maximilians-Universität München (LMU)
As one of Europe's leading research universities, LMU Munich is committed to the highest international standards of excellence in research and teaching. Building on its 500-year-tradition of scholarship, LMU covers a broad spectrum of disciplines, ranging from the humanities and cultural studies through law, economics and social studies to medicine and the sciences.
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