Chemical biology is a burgeoning field that has rapidly risen to prominence. This surge of interest has been fuelled by chemical biology’s applicability to understanding critical processes in live cells or model organisms in real time. This success has arisen because chemical biology straddles a nexus between chemistry, biology, and physics. Thus, chemical biology can harness rapid chemistry to observe or perturb biological processes, that are in turn reported using physical assays, all in an otherwise unperturbed living entity.
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Chemical Biology
Университет ЖеневыОб этом курсе
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Средний уровень
Basic training in chemistry biology and physics.
Прибл. 21 час на выполнение
Английский
Субтитры: Французский, Португальский (Европа), Русский, Английский, Испанский
Чему вы научитесь
Foundational comprehension of chemical biology
Interfacial science problem solving and method design
Understanding of applied, translational concepts in life sciences
Сертификат, ссылками на который можно делиться с другими людьми
Получите сертификат по завершении
100% онлайн
Начните сейчас и учитесь по собственному графику.
Гибкие сроки
Назначьте сроки сдачи в соответствии со своим графиком.
Средний уровень
Basic training in chemistry biology and physics.
Прибл. 21 час на выполнение
Английский
Субтитры: Французский, Португальский (Европа), Русский, Английский, Испанский
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Университет Женевы
Founded in 1559, the University of Geneva (UNIGE) is one of Europe's leading universities. Devoted to research, education and dialogue, the UNIGE shares the international calling of its host city, Geneva, a centre of international and multicultural activities with a venerable cosmopolitan tradition.
Программа курса: что вы изучите
4 ч. на завершение
Welcome to Chemical Biology: Concepts and techniques
A very warm welcome to you, our new recruits! We'll start you off by acquainting you with the answers to big questions like why study chemical biology and what makes it special. We'll then show some highlights of the course that you are about to take. Finally, we want you to understand some fundamentals, so we are going to start off with some core concepts framed from the perspective of chemical biology.
4 ч. на завершение
8 видео ((всего 58 мин.)), 7 материалов для самостоятельного изучения, 4 тестов
8 видео
Trailer1мин
Welcome1мин
Why study chemical biology?11мин
Course outline and highlights9мин
The building blocks: monomeric units of proteins9мин
The building blocks: monomeric units of DNA and membranes8мин
Messengers and messages: posttranslational modifications, and pathways8мин
Studying cellular processes with chemical biology in real time8мин
7 материалов для самостоятельного изучения
Course Acknowledgements5мин
How assessments work10мин
The foundation: the cell10мин
The workhorses: proteins, enzymes12мин
Classical protein readouts12мин
Flash mob: overview of protein analysis methods10мин
Flash mob - Chemistry15мин
4 практических упражнения
Components of a cell22мин
Amino acids24мин
Match technique to goal15мин
Final Quiz Number 128мин
3 ч. на завершение
The Devil is in the Minutest Detail
A picture used to paint a thousand words. But with the advent of multiple color imaging, microscopy can open a lens with which to view life that few other techniques are capable of. We are thus going to take you on a colorful tour that will show you specific fluorophores, explain why different fluorophores have different colors, and how to rationalize why a molecule is fluorescent. Then we will use these fluorophores in cells, to visualize important cellular processes.
3 ч. на завершение
5 видео ((всего 37 мин.)), 5 материалов для самостоятельного изучения, 3 тестов
5 видео
Light'em up! Fluorophores: structures, and fluorescent principles9мин
Get out (almost) what you put in!3мин
Traditional light microscopy – applications10мин
Traditional light microscopy – precautions10мин
5 материалов для самостоятельного изучения
Physics of fluorescence15мин
Fluorescent proteins10мин
RNA interference and genome editing20мин
Plasmids and transfection15мин
DNA double stranded breaks and γ-H2AX10мин
3 практических упражнения
Jablonski diagram16мин
Match color of fluorophore to structure20мин
Final Quiz Number 222мин
4 ч. на завершение
A ruler over time and space! Fluorescent assays to measure complex parameters in real time
Here we will discuss how different fluorescent techniques have found fantastically useful applications to understand specific biological regulation processes in vitro and in live cells. We will focus on chromatin regulation and regulation of membrane tension as these are two systems which, without such techniques, we would not have the level of understanding we have today.
4 ч. на завершение
12 видео ((всего 88 мин.)), 5 материалов для самостоятельного изучения, 6 тестов
12 видео
Creating modified chromatin 9мин
PRC2, a DNA binding complex linked to development and cancer7мин
TIRF talk7мин
On our TIRF4мин
If your protein surfs on DNA, hit the TIRF to study it8мин
PHF1 Prolongs the stable PRC2-DNA complex, promoting activity8мин
Fluid mosaic model5мин
Don’t get uptight! New methods to measure membrane tension7мин
Getting a grip on membrane tension measurements4мин
TORCing TORC: the many faces of the TOR proteins8мин
TORCing it out: pathways that seek to sense and restore membrane tension13мин
5 материалов для самостоятельного изучения
DNA organization in eukaryotes is linked to regulation10мин
Kinetics of chemical reactions6мин
Comparing chemical structures6мин
Flash mob inteins6мин
Model Organisms20мин
6 практических упражнений
Making proteins via expressed protein ligation and alkylation18мин
Hit the tirf: applications of TIRF microscopy11мин
Analyzing data from TIRF experiments to gain mechanistic insights17мин
Modern fluorescence methods, the spark of creativity15мин
TORCing about Tor's role in membrane tension regulation16мин
Final Quiz 325мин
5 ч. на завершение
Putting proteins to work for us
The classical view of biological science is the laboratory worker working hard to understand a specific protein of interest. But through chemical biology, we have been able to employ proteins to do some of this important work for us. In this module you will learn how to deploy modified protein domains to perform custom-designed functions using light-based techniques as a readout.
5 ч. на завершение
11 видео ((всего 95 мин.)), 3 материалов для самостоятельного изучения, 7 тестов
11 видео
Tracking a specific protein in live cells & in real time8мин
Molecular zipcodes4мин
How to design your fusion protein6мин
Design principle and optimization of SNIFITs7мин
SNIFITs to ID neurotransmitters and drugs10мин
Application to point of care diagnosis7мин
Biological electrophiles, the cell’s way of saying “I’m stressed”?8мин
Breaking the tether is not that bad10мин
T-REX: a question of control(s)16мин
T-REX rewiring of kinase activity through targeting AKT and PTEN: opposing forces meet 10мин
3 материала для самостоятельного изучения
Many enzyme mechanisms proceed through a covalent enzyme intermediate that can be stabilized through mutagenesis10мин
Small molecule signals8мин
Weighing up our options10мин
4 практических упражнения
Optimal considerations for making fusion proteins and employing them in chemical biology24мин
Optimal considerations for making fusion proteins and employing them in chemical biology214мин
A bit on the nose? Chose the right SNIFITs20мин
Final Quiz Number 424мин
Рецензии
Лучшие отзывы о курсе CHEMICAL BIOLOGY
от партнера MF2 дек. 2020 г.
With due respect sir, I would like to say you that I have problem with the quiz system. I can't tell which on of my answer is right or wrong. Please sir, mark the right anwers in green
от партнера GG23 дек. 2020 г.
Amazing course, the best one i enrolled in so far here, very well build and got used to the simple fantastic teaching of Dr. Marcus Long, glad to have spent time studying this topic
от партнера RI15 нояб. 2020 г.
Very challenging yet interesting topic. This is 21st century science towards revolutionizing Systems Biology and other science fields
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