Об этом курсе
4.5
Оценки: 33
Рецензии: 11
Nerves, the heart, and the brain are electrical. How do these things work? This course presents fundamental principles, described quantitatively....
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Intermediate Level

Промежуточный уровень

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Approx. 22 hours to complete

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English

Субтитры: English...
Globe

Только онлайн-курсы

Начните сейчас и учитесь по собственному графику.
Calendar

Гибкие сроки

Назначьте сроки сдачи в соответствии со своим графиком.
Intermediate Level

Промежуточный уровень

Clock

Approx. 22 hours to complete

Предполагаемая нагрузка: 6 hours/week...
Comment Dots

English

Субтитры: English...

Программа курса: что вы изучите

Week
1
Clock
3 ч. на завершение

Electricity in Solutions

This week's theme focuses on the foundations of bioelectricity including electricity in solutions. The learning objectives for this week are: (1) Explain the conflict between Galvani and Volta; (2) Interpret the polarity of Vm in terms of voltages inside as compared to outside cells; (3) Interpret the polarity of Im in terms of current flow into or out of a cell.; (4) Determine the energy in Joules of an ordinary battery, given its specifications; (5) State the “big 5” electrical field variables (potentials, field, force, current, sources) and be able to compute potentials from sources (the basis of extracellular bioelectric measurements such as the electrocardiogram) or find sources from potentials....
Reading
12 видео (всего 66 мин.), 5 материалов для самостоятельного изучения, 2 тестов
Video12 видео
What is the Question5мин
About Bioelectricity5мин
Major Sections of the Course5мин
Rectification of Names10мин
Ions in Solution6мин
Core-Conductor Model of a Nerve Fiber9мин
Potential and Voltages in the Fiber5мин
Axial Currents in the Fiber5мин
Membrane Resistance3мин
Membrane Current, Failure & Mystery3мин
Week 1 in Review4мин
Reading5 материала для самостоятельного изучения
Welcome to the Courseмин
Assessments, Grading and Certificates10мин
Course Lecture Slides10мин
Discussion Forums10мин
Reference Text10мин
Quiz2 практического упражнения
Quiz 1A10мин
Quiz 1B16мин
Week
2
Clock
2 ч. на завершение

Energy into Voltage

This week we will examine energy, by which pumps and channels allow membranes to "charge their batteries" and thereby have a non-zero voltage across their membranes at rest. The learning objectives for this week are: (1) Describe the function of the sodium-potassium pump; (2) State from memory an approximate value for RT/F; (3) Be able to find the equilibrium potential from ionic concentrations and relative permeabilities; (4) Explain the mechanism by which membranes use salt water to create negative or positive trans-membrane voltages....
Reading
12 видео (всего 76 мин.), 2 тестов
Video12 видео
A Membrane Patch; the Idea of It7мин
Energy as Trans-membrane Voltage Vm3мин
Sodium-potassium Pumps4мин
Ionic equilibrium13мин
Battery lifetime5мин
Problem session 14мин
Membrane Resistance Rm9мин
Membrane capacitance Cm4мин
Why is Cm so big?7мин
Problem session, R and C8мин
Week 2 summary5мин
Quiz2 практического упражнения
Quiz 2A20мин
Quiz 2B12мин
Week
3
Clock
2 ч. на завершение

Passive and Active Resonses, Channels

This week we'll be discussing channels and the remarkable experimental findings on how membranes allow ions to pass through specialized pores in the membrane wall. The learning objectives for this week are: (1) Describe the passive as compared to active responses to stimulation; (2) Describe the opening and closing of a channel in terms of probabilities; (3) Given the rate constants alpha and beta at a fixed Vm, determine the channel probabilities; (4) Compute how the channel probabilities change when voltage Vm changes....
Reading
12 видео (всего 82 мин.), 1 материал для самостоятельного изучения, 3 тестов
Video12 видео
Why are passive and active so different?3мин
The simulation set-up9мин
The passive simulation11мин
The active simulation11мин
Where does the active response come from?8мин
Problem session, passive v active6мин
Channels: Experimental isolation of a channel7мин
Channels: Observed currents, voltage step4мин
Channels: Probability of being open6мин
Problem session, Channel probabilities8мин
Week 3 Conclusions4мин
Reading1 материал для самостоятельного изучения
Alpha Beta Programming Assignment Instructions10мин
Quiz3 практического упражнения
Quiz 3A12мин
Quiz 3B18мин
Alpha Beta Programming Assignment24мин
Week
4
Clock
3 ч. на завершение

Hodgkin-Huxley Membrane Models

This week we will examine the Hodgkin-Huxley model, the Nobel-prize winning set of ideas describing how membranes generate action potentials by sequentially allowing ions of sodium and potassium to flow. The learning objectives for this week are: (1) Describe the purpose of each of the 4 model levels 1. alpha/beta, 2. probabilities, 3. ionic currents and 4. trans-membrane voltage; (2) Estimate changes in each probability over a small interval $$\Delta t$$; (3) Compute the ionic current of potassium, sodium, and chloride from the state variables; (4) Estimate the change in trans-membrane potential over a short interval $$\Delta t$$; (5) State which ionic current is dominant during different phases of the action potential -- excitation, plateau, recovery....
Reading
12 видео (всего 95 мин.), 1 материал для самостоятельного изучения, 3 тестов
Video12 видео
What is the Problem8мин
HH replacement for Rm5мин
The equation for each pathway10мин
Changes in n, m, h11мин
Equations for alphas and betas18мин
Problem session, I_Na9мин
Putting it all together6мин
Changes in n, m, h, and Vm5мин
Numerical calculations, time and space6мин
Problem session, a Vm step4мин
Week 4 conclusions5мин
Reading1 материал для самостоятельного изучения
Action Potential Programming Assignment10мин
Quiz3 практического упражнения
Quiz 4A16мин
Quiz 4B20мин
Action Potential Programming Assignment18мин
4.5

Лучшие рецензии

автор: JRSep 25th 2016

Very clear expectations, and the lectures were spaced out nicely to cover material while not being overwhelming. Additionally, the analogies used to convey the principles were clever and helpful!

автор: AJJan 15th 2018

Interesting class which derived mathematical models that were, and are still used, to describe nerves.

Преподаватель

Dr. Roger Barr

Anderson-Rupp Professor of Biomedical Engineering and Associate Professor of Pediatrics
Biomedical Engineering, Pediatrics

О Duke University

Duke University has about 13,000 undergraduate and graduate students and a world-class faculty helping to expand the frontiers of knowledge. The university has a strong commitment to applying knowledge in service to society, both near its North Carolina campus and around the world....

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